• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 589-591.DOI: 10.3969/j.issn.1671-2587.2019.06.009

• 临床检验 • 上一篇    下一篇

结核γ干扰素释放试验在结核病诊断中的价值*

尹美玲, 李明, 崔花芹, 单武林, 阚劲松   

  1. 230031 合肥,中国科学技术大学附属第一医院西区,安徽省肿瘤医院检验科
  • 收稿日期:2018-08-07 出版日期:2019-12-20 发布日期:2019-12-25
  • 通讯作者: 李明,男,副主任技师,硕士,主要从事肿瘤生物学研究,(E-mail)liming19831002@163.com。
  • 作者简介:尹美玲(1985-),女,主管检验师,硕士,主要从事临床微生物学检验工作,(Tel)15056001288。
  • 基金资助:
    *本课题受安徽省自然科学基金(No.1308085QH144)资助

Clinical Application of Tuberculosis - Interferon Gamma Release Assay in The Diagnosis of Tuberculosis

YIN Mei-ling, LI Ming, CUI Hua-qin, et al   

  1. Department of Laboratory Diagnostics,Western Branch of The First Affiliated Hospital of University of Science and Technology of China,Anhui Provincial Cancer Hospital,Hefei,Anhui 230031
  • Received:2018-08-07 Online:2019-12-20 Published:2019-12-25

摘要: 目的 探讨结核γ干扰素释放试验(tuberculosis - interferon gamma release assay,TB-IGRA)在结核病诊断中的应用价值。方法 选取某院2015年9月~2017年6月进行TB-IGRA检测的756例患者为研究对象,对其临床资料和结核相关性实验室检查进行回顾性分析。结果 结核患者TB-IGRA检测阳性率为87.31%,其中肺结核组和肺外结核组患者TB-IGRA检测的阳性率分别为85.55%和90.80%,高于非结核组(P<0.001);结核患者TB-IGRA检测的阳性率高于抗酸染色镜检、结核抗体检测和胸腹水ADA检测的阳性率(P<0.001);结核患者的年龄、性别、基础疾病、结核发生部位、全血淋巴细胞数目、结核活动程度等对TB-IGRA检测水平无明显影响。结论 TB-IGRA试验在肺结核和肺外结核检测中具有较高的阳性率,可以作为结核病的辅助诊断。

关键词: 结核γ干扰素释放试验, 抗酸染色, 结核抗体, ADA

Abstract: Objective To evaluate the clinical value of tuberculosis-interferon gamma release assay (TB-IGRA) in the diagnosis of tuberculosis. Methods A retrospective analysis of the clinical data from 756 hospitalized patients,who received TB-IGRA test from Sep 2015 to Jun 2017,was performed. Results The positive rate of TB-IGRA was 87.31% in TB patients,and the positive rate of TB-IGRA was 85.55% and 90.80% respectively in the patients with pulmonary tuberculosis and extrapulmonary tuberculosis,significantly higher than that in the patients without tuberculosis (P<0.001); there was significantly higher detectable rate in TB patients by TB-IGRA than by anti-acid staining,detection of TB antibody, and the detection of ADA in hydrothorax and ascites (P<0.001); there were no statistical differences in the detection level of TB-IGRA between different ages,sex,basic diseases,tuberculosis sites,lymphocyte counts,and tuberculosis activity.Conclusion sTB-IGRA had higher diagnostic value in the detection of pulmonary tuberculosis and extrapulmonary tuberculosis. TB-IGRA can be used as auxiliary diagnosis of tuberculosis.

Key words: TB-IGRA, Anti-acid staining, TB-AB, ADA

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