Abstract: Abstract Objective: To investigate the clinical blood usage-disease, we counted and analyzed the clinical data of the patients with severe neonatal hyperbilirubinemia in our hospital, and obtained valuable reference information for the reasonable blood storage of department of blood transfusion, the planned blood collection of blood bank, and the clinical work in the future. Method: We collected the clinical data of 389 exchange transfusion patients from January 2016 to December 2019 in Wuhan children’s hospital, Tongji Medical College of Huazhong University of Science& Technology.Statistical analysis was carried out on the blood use amount of suspension red blood cells and fresh plasma. Result: In 389 cases of exchange transfusion,212 cases were male, 177 cases were female, and the gender difference was not significant（P＞0.05）.155 cases were A blood type, 128 cases were B blood type, 80 cases were O blood type, and 26 cases were AB blood type. There was significant difference among different blood types（P＜0.001）. The total blood use amount of suspended red blood cells was 1060U, AB frozen plasma was 49050ml, and the average use of suspension red blood cells was 3.13U, frozen plasma was 165ml.Conclusion: Through the analysis of exchange transfusion of patients with severe neonatal hyperbilirubinemia in our hospital, we can summarize the blood preparation experience of exchange transfusion in order to make blood storage plan for blood transfusion department, and feedback the result to the blood bank in order to make their blood sampling evidence-based. We strive to achieve reasonable preparation of blood, safe use of blood and saving blood.

Key words: Keywords: neonatal hyperbilirubinemia, exchange transfusion, reasonable use