Abstract: Objective To investigate application value of bone marrow biopsy detection of acute leukemia minimal residual disease. Method s78 cases of adult acute leukemia patients in our hospital during the period January 2013 - January 2014 were treated as the research object,using bone marrow biopsy after chemotherapy,12,24 ,36 and 48 months in patients with bone marrow smear and biopsy of implementation,comparison of bone marrow cytology and bone marrow biopsy Results,statistical processing. Results A total of 78 patients with bone marrow biopsy were performed 290 times in this group. The positive aspects of minimal residual lesions were 12 months and 24 months,36 months and 48 months,and the difference was significant （P<0.05）.In minimal residual lesions and recurrence： there were minimal residual lesions in 12 and 24 months,and 2 patients relapsed after chemotherapy,there were no minimal residual lesions in 1 cases,and 1 patients with minimal residual disease. Minimal residual lesions were positive in the continuous remission group. Conclusion Bone marrow biopsy is safe and convenient,and it has a certain reference value for the detection of minimal residual disease in adult patients with acute myeloid leukemia.

Key words: Adult acute leukemia, Minimal residual disease, Bone marrow biopsy