Abstract: Objective To explore the efficacy of local injections via fiberoptic bronchoscopy for the patients with multi-drug resistant tuberculosis. Methods Ninety eight cases of patients with multi-drug resistant tuberculosis were divided into the experiment group （50 cases,3DVThAE/15DVThE+local injections via fiberoptic bronchoscopy） and control group（48 cases,3DVThAE/15DVThE only）. The clinical effects and immune status of the patients were compared. Results The sputum negative conversion rates for 3 months,6 months,and 12 months in the experiment group were higher than those in the control（P<0.05）. The total rates of lesions disapperance and cavity reduction of the lung were higher in the experiment group than those in the control（P<0.05）. The higher levels of CD4+,CD4+/CD8+ and IFN-γ expression were seen in the experiment group than the control（P<0.05）. The number of CD8+ was decreased in the experiment group （P<0.05）. In contrast,IL-4 level was found to be reduced in the experiment group（P<0.05）. Conclusion Local injections via fiberoptic bronchoscopy is promising for the treatment of patients with multi-drug resistant tuberculosis,

Key words: Fiberobronchoscopy, Local injection, Multi-drug resistant tuberculosis