Abstract: Objective To investigate the drug resistance of Carbapenem-intermediate Enterobacteriaceae （CIE）,and whether carrying carbapenemases gene. Methods 26 CIE isolates were collected from March 2015 to January 2017 in the North District of Affiliated Suzhou Hospital,Nanjing Medical University,drug resistance of these isolates were investigated by antibiotic susceptibility testing. Carbapenemase genes KPC,NDM,IMP,VIM and OXA48 were detected by polymerase chain reaction （PCR）. Results More than 80% of 26 CIE clinical isolates were resistance to ampicillin,cefazolin,ceftazidime. PCR detected 6 isolates carrying carbapenemase genes,including 4 isolates of KPC,1 isolate of NDM and 1 isolate was IMP positive. Conclusion The multidrug resistance rate in carbapenems-intermediate Enterobacteriaceae was high,and the carbapenemases gene positive isolates were also account for a certain proportion,which suggests that the clinical monitoring of multiple drug-resistant bacteria needs to be further strengthen.

Key words: Enterobacteriaceae, Multidrug resistance, Carbapenemases gene