Abstract: Objective To investigate the effect of dexamethasone (DX) combinated with caffeic acid tablet (CAT) on PAIg G and GPⅡb/Ⅲa levels in patients with primary immune thrombocytopenia (ITP). Methods Eighty patients with ITP in the hospital were selected from August 2014 to March 2017 and randomly divided into two groups, with 40 cases in each. The control group only received CAT, while the observation group was given DX and CAT. Clinical efficacy and PAIg G and GPⅡb/Ⅲa levels were compared between the two groups. Results The CR, R and NR rates did not reveal any significant difference on d14, d28 and w12 after treatments. Similarly, the bleeding score, PAIg G and GPⅡb/Ⅲa levels showed no remarkable differences before treatments（P>0.05）but obviously decreased after treatments in the observation group compared with the control （P<0.05）. Conclusion Compared with dexamethasone treatment, dexamethasone combined with caffeic acid tablet did not improve the therapeutic outcomes in the treatment of ITP patients in terms of laboratory tests. However, the combination therapy can effectively ameliorate the bleeding symptoms and reduce the antibody levels of PAIg G and GPⅡb /Ⅲa.

Key words: Dexamethasone, Caffeic acid, Primary immune thrombocytopenia, PAIg G, GPⅡ b/Ⅲ a