Abstract: Objective To investigate the effects of high-flux hemodialysis on inflammatory factors and immune function in patients with diabetic nephropathy.Methods Fifty patients with diabetic nephropathy were enrolled in this study. Patients were divided into two groups： conventional dialysis group （control group） and high-throughput dialysis group （25 cases）. The treatment time was 12 weeks. The changes of T lymphocyte subsets （CD3⁺,CD4⁺,CD4⁺ / CD8⁺）,immunoglobulin （IgA,IgG,IgM） and the levels of IL-6 and TNF-α.ResultsThere was no significant difference in T lymphocyte subsets,immunoglobulin （IgA,IgG,IgM）,serum IL-6 and TNF-α in peripheral blood after dialysis treatment in the control group（P>0.05）; There was no significant difference in the level of IgA,IgG,IgM between the two groups after dialysis （P>0.05）. The number of T lymphocyte subsets was significantly higher than that before treatment,and the levels of IL-6 and TNF-αlevels were significantly lower than before treatment（P>0.05）,and compared with the control group after treatment,the difference was statistically significant（P>0.05）.Conclusion High-throughput hemodialysis can reduce the levels of inflammatory cytokines and immune function in patients with diabetic nephropathy.

Key words: High-flux hemodialysis, Immunoglobulins, T-lymphocyte substes, Inflammation