Abstract: Objective To investigate the diagnostic effect of platelet function analyzer（PFA）-200P2Y and Light transmittance aggregometry（LTA）on clopidogrel resistance（CR）and analyze the relevant factors for CR. Methods Ninety-five patients with acute cerebral infarction were selected from Nanjing Drum Tower Hospital from January 2018 to December 2018. All patients were treated with clopidogrel 75 mg/d for more than 3 days, platelet function was measured by PFA-200P2Y and LTA methods. The incidence of CR detected by the two methods was calculated and the correlation between the results of the two methods was analyzed. The patients were divided into CR group and N-CR（non-clopidogrel resistance）group according to the test results. The differences of clinical factors between the two groups were compared, and the related factors that may influence the occurrence of CR were analyzed by Logistic regression. Results 22（23.2%）CR patients were detected by PFA-200P2Y and 53（55.8%）CR patients were founded by LTA. There was significant difference between the two methods（χ²= 21.170,P<0.001）. Univariate analysis showed that there were significant differences in blood homocysteine （χ²=8.589, P=0.004）and white blood cell count（χ²=5.537,P=0.021）between the CR and N-CR groups according to LTA grouping. Logistic regression analysis showed that white blood cell count（OR=1.551,P=0.010）was an independent risk factor for CR, and homocysteine（OR=0.916,P=0.037）was an independent protective factor for CR. Conclusion The consistency between the results of PFA-200P2Y and LTA methods in detecting clopidogrel resistance in patients with acute cerebral infarction is poor. Homocysteine was an independent protective factor and increased leukocyte count was an independent risk factor for CR.

Key words: PFA-200 P2Y LTA, Acute cerebral infarction, Clopidogrel resistance