Abstract: Plasma, as the common blood components, has been widely used to supplement coagulation factors, which can prevent or treat bleeding or bleeding tendency caused by coagulation factor deficiency. Although the concept of rational and scientific transfusion has been implemented for many years, the majority of plasma transfusions are still sub-optimal, and achieving optimal plasma utilization is an ongoing challenge. Based on the domestic and international blood transfusion guidelines and published relevant clinical studies, this article reviews the current status, applications and challenges of plasma transfusion, looks forward to the future development, and update and expand the existing guidelines.

Key words: Plasma transfusion, Blood management, Adverse transfusion reaction