Abstract: Objective The study aimed to elucidate the prognostic value of CD36 in cancer and its relationship with immune infiltration across different cancer types.Bioinformatics methods were employed to study the expression of blood type gene CD36 in human malignant tumors and its relationship with prognosis, clinical staging, and immune infiltration. Methods UALCAN database was used to analyze the difference of CD36 protein expression between tumor tissues and normal tissues. GEPIA database was used to analyze the relationship between CD36 expression and pan-cancer stage. The SangerBox database was used to analyze the relationship between CD36 expression and the survival prognosis of pan-cancer patients, the correlation between CD36 expression and immune infiltration in pan-cancer, the correlation between CD36 expression and TMB,MSI, etc., and the String database was used to analyze the upstream and downstream proteins related to CD36. Results There was significant upregulation of the CD36 gene in 9 types of tumors (P<0.05), while significant downregulation was observed in 18 types of tumors (P<0.05). The expression levels of CD36 were closely associated with the staging and prognosis of different types of cancer patients. CD36 plays different roles in different types of tumors. The expression of CD36 in 39 cancer types was significantly positively correlated with immune infiltration (P<0.05), suggesting its important role in regulating the tumor immune environment. KEGG and GO enrichment analysis showed that candidate genes mainly participate in toll-like receptor signaling pathway, NF-κB signaling pathway, and immune response activation signaling. Conclusion CD36 exhibits expression variations in different tumors, and its expression is closely associated with the staging and prognosis of various cancer patients. Blood type CD36 gene is expected to serve as an important prognostic predictor for tumors.

Key words: Blood type CD36 gene, Pancancer analysis, Tumor microenvironment, Immune infiltration