Abstract: Objective Through the research of many cases of mimicking antibodies, To study the characteristics of mimicking antibodies and explore the transfusion principles of mimicking antibodies. Provide effective detection methods and clinical suggestions for patients with mimicking antibodies. Methods A retrospective analysis was made on the sex, age, diagnosis and serological test of 160 cases of mimicking antibodies. Analyze the experimental data and find the relevant rules. Results The specificity of RH blood group antibodies is the most common in all mimicking antibodies. Mimicking antibodies of anti-Ce, anti-Ec and anti-D accounted for 94.48% in 160 cases. The type of CCDee is the most common type in all cases. GEL test in serum showed strong antibody reactivity (the score was 7.16). Indirect antiglobulin test in serum with tube showed strong specificity. Conclusion It is suggested that a variety of identification methods should be employed because it's difficult to identify the specificity of mimicking antibodies. The GEL test is more reactive in detecting antibodies and Indirect antiglobulin test method is more specific in distinguishing antibodies. The two methods should be combined. Blood transfusion treatment should be as far as possible to avoid mimicking antibody specificity, transfuse corresponding antigen negative of red blood cells will have obvious therapeutic effect on the patients.

Key words: Mimicking antibody, Autoantibody, Mimicking anti-Ce, Indirect antiglobulin test