Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation

doi:10.3969/j.issn.1671-2587.2025.05.010

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 649-654.DOI: 10.3969/j.issn.1671-2587.2025.05.010

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Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation

CHEN Mengke, XIA Rong

Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040

Received:2025-08-31 Revised:2025-09-09 Online:2025-10-20 Published:2025-10-11

Abstract

Abstract: Aging is a multifactorial, system-wide process of functional decline and is a major risk factor for various chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. In recent years, the use of blood and blood-derived products as potential anti-aging therapies has attracted considerable attention. Studies suggest that growth factors, cytokines, and small-molecule metabolites in young blood components exhibit significant tissue repair and anti-aging effects, promoting neurogenesis, enhancing cellular regeneration, and regulating metabolic homeostasis, thereby improving health in older individuals. Young plasma has been found to reverse neurological decline, improve cardiovascular function, reduce liver fibrosis, and enhance kidney function, showing anti-aging potential across various organs. Current clinical trials of young plasma focus on neurodegenerative diseases such as Alzheimer's and Parkinson's, demonstrating safety and good tolerance in small-scale studies. However, the long-term efficacy and safety of this therapy remain to be validated, and ethical and resource considerations require careful evaluation. This review summarizes research progress on blood and blood-derived products as anti-aging therapies, with a focus on their regenerative effects on the nervous, cardiovascular, hepatic, and renal systems/organs, and consolidates findings from related clinical trials to support further clinical applications in anti-aging interventions.

Key words: Aging, Blood-derived products, Research progress, Clinical applications

CLC Number:

R457.1

CHEN Mengke, XIA Rong. Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 649-654.

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Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation

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