Progress in Preoperative Anemia Intervention Research for Adult Cardiac Surgery

doi:10.3969/j.issn.1671-2587.2025.06.020

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (6): 867-876.DOI: 10.3969/j.issn.1671-2587.2025.06.020

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Progress in Preoperative Anemia Intervention Research for Adult Cardiac Surgery

CHEN Yuye¹, SHAN Jiachen¹, GAO Jie¹, GAO Yuan², SHI Jia¹, JI Hongwen^1,3

¹Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037;
²Department of Blood Transfusion, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037;
³Chinese Academy of Medical Sciences Fuwai Hospital Shenzhen Hospital, Guangdong 518057

Received:2025-06-12 Published:2025-12-24

Abstract

Abstract: Preoperative anemia occurs in 10% to 30% of adult patients undergoing cardiac surgery, leading to a range of adverse postoperative outcomes. Evidence suggests that implementing targeted management strategies for preoperative anemia can effectively reduce the risk of complications, including postoperative infections, organ dysfunction, and mortality. Current clinical practice presents a diverse array of intervention strategies; however, their efficacy and safety remain to be subjects of ongoing debate. This article systematically reviews the pathophysiological mechanisms underlying preoperative anemia and summarizes the effectiveness and limitations of common interventions such as iron supplementation, erythropoietin administration, and protocols for vitamin B₁₂ and folic acid supplementation, Additionally, it introduces several novel therapeutic approaches for anemia, and provides an overview of comprehensive Patient Blood Management (PBM). Our aim is to offer a reference for personalized clinical management and further research on preoperative anemia.

Key words: Cardiac surgery, Preoperative anemia, Iron supplemen, Erythropoietin, Patient blood management

CLC Number:

R654.2

CHEN Yuye, SHAN Jiachen, GAO Jie, GAO Yuan, SHI Jia, JI Hongwen. Progress in Preoperative Anemia Intervention Research for Adult Cardiac Surgery[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(6): 867-876.

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Progress in Preoperative Anemia Intervention Research for Adult Cardiac Surgery

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