Abstract: Objective To study the application value of examining coagulation indicator and platelet indicators in research for hepatic cirrhosis,and to discuss the clinical significance,so as to provide theory evidence for the diagnosis and treatment of hepatic cirrhosis. Method 80 cases of patients with hepatic cirrhosis treated in our hospital since January 2014 to January 2015 and 80 cases of normal people were selected as the object of study. Patients with hepatic cirrhosis were set as observation group,while normal people were set as control group. Patients in observation group were divided into level A,level B and level C in accordance with hepatic cirrhosis Child-Pugh classification standard. People in groups mentioned above were detected for platelet indicators and coagulation indicator via hematology analyzer and coagulometer. Platelet indicators includes platelet distribution width （PDW）,platelet count （PLT）,mean platelet volume （MPV） and plateletcrit （PCT）,while coagulation indicator includes Fibrinogen （FIB）,prothrombin time （PT）,thrombin time （TT） and activated partial thromboplastin time （APTT）. Results There was a significant difference in Platelet PDW,PLT,MPV and PCT between observation group and control group,and a significant difference in coagulation indicator FIB,PT,TT and APTT between observation group and control group,having statistical significance （P<0.05）. In comparison among hepatic cirrhosis Child-Pugh classification,the platelet indicator gradually decreased from level A,level B to level C. There was a distinct difference between group B &C and group A,and there was a significant difference between level B and level C in MPV,PLT and PCT,having statistical significance （P<0.05）. PDW had no statistical significance （P>0.05）. As for coagulation indicator in level A,level B and level C,TT,APTT and PT gradually increased,while FIB gradually decreased. There was a significant difference between group B&C and group A,and there was no significant difference in APTT and FIB between level B and level C （P>0.05）. PT and TT differ distinctly,having statistical significance （P<0.05）.Conclusion Compared with normal people,various coagulation indicators and platelet indicators of patients with hepatic cirrhosis were abnormal,and indicators vary in accordance with the severity of hepatic cirrhosis. Coagulation indicator and platelet indicator can reflect the severity of hepatic cirrhosis of patients,significantly for the diagnosis and treatment of hepatic cirrhosis.

Key words: Hepatic cirrhosis, Platelet indicator, Coagulation indicator