Abstract: Objective To explore the predictive value of serum and urinary PTX-3 in recent occurrence of acute kidney injury (AKI) in critical patients. Methods A total of 217 critical patients were classified into AKI group (n=87) and non-AKI group (n=130) based upon the guideline of KDIGO, the levels of serum and urinary PTX-3 were detected by using ELISA, the predictive value of PTX-3 for the recent occurrence of AKI was analyzed by area under the receiver operating characteristic curve. Results The shocking rate, APACHE Ⅱ score, SCr level, and PTX-3 level in AKI group were markedly higher than those in non-AKI group (P<0.05). Besides, the level of PTX-3 in the classes 2 and 3 group were significantly elevated compared with that in class 1 group (P<0.05). However, no significant difference was noted between class 2 and class 3 (P>0.05). The level of PTX-3 was an independent risk factor for the prediction of AKI (all P<0.05). Moreover, both serum and urinary PTX-3 had a positive correlation with SCr (all P<0.05). The AUC value of PTX-3 was 0.875 and 0.868, respectively, which relatively higher than that of SCr (AUC=0.747, P<0.05). The AUC of PTX-3 for prediction of classes 1 and 2 AKI was 0.858 and 0.829, respectively, which was more reliable than that of SCr (AUC=0.727, P<0.05). Conclusion Serum and urinary PTX-3 may effectively predict the occurrence of AKI in critical patients when served as a potential biomarker for diagnosis of AKI in the early stage.

Key words: Pentraxin 3, Acute kidney injury, Critical patient, Serum creatinine