Progress in the Study of the Mechanism of Attenuation or Absence of ABO Blood Group Antigens in Erythrocytes

doi:10.3969/j.issn.1671-2587.2025.05.016

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 689-694.DOI: 10.3969/j.issn.1671-2587.2025.05.016

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Progress in the Study of the Mechanism of Attenuation or Absence of ABO Blood Group Antigens in Erythrocytes

WANG Xinrui, YANG Hongyan, QIN Ranran, GAO Yuhan, HOU Ruiqin

Department of Blood Transfusion, Peking University People's Hospital, Beijing 100044

Received:2025-09-01 Revised:2025-09-09 Online:2025-10-20 Published:2025-10-11

Abstract

Abstract: The ABO blood group system is a crucial component of blood transfusion. Attenuation or absence of ABO antigens on red blood cells is occasionally observed, posing significant challenges to blood group determination. The occurrence of such phenomena may be associated with physiological, genetic, or pathological factors. The underlying causes and mechanisms of weakened or absent ABO antigens are highly complex; recent studies have primarily focused on variations within the ABO gene coding region, promoter region, untranslated regions at the 5' and 3' ends, as well as intronic regions. This article provides an analytical summary of the potential causes and mechanisms underlying the attenuation or absence of ABO blood group antigens, offering a theoretical basis for accurate identification of complex blood groups, enriching the research on ABO blood group variants in the Chinese population, and ensuring the safety and effectiveness of clinical transfusion practice.

Key words: ABO blood group antigens, ABO subtypes, Safety of blood transfusion

CLC Number:

R457.1⁺1

WANG Xinrui, YANG Hongyan, QIN Ranran, GAO Yuhan, HOU Ruiqin. Progress in the Study of the Mechanism of Attenuation or Absence of ABO Blood Group Antigens in Erythrocytes[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 689-694.

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Progress in the Study of the Mechanism of Attenuation or Absence of ABO Blood Group Antigens in Erythrocytes

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