Abstract: Objective To explore whether the effect of autologous platelet separation and transfusion on patients with different platelet counts is similar to each other and to find the best application range of that in aortic dissection. Methods 300 patients with aortic dissection who accepted cardiac surgery in 2014 to 2019, with age arranged from 22 to 79 years and with weight from 50 to 85 kg, were divided into four grades according to preoperative platelet count：（100~ 150）×10⁹/L,（150~200）×10⁹/L, （200~250）×10⁹/L,（250~300）×10⁹/L. And each grade was randomly divided into two groups：control group and aPRP group（the patients received autologous PRP）.The whole plateletpheresis process was completed before heperinization. Analyze the transfusion volume of allogeneic platelet,suspended red cells, plasma and cryoprecipitate of two groups during perioperative stage. Results There were no significant differences between control group and aPRP group in ages, weights, heights and PLT count before operation（P>0.05）in 300 patients. The amounts of allogeneic platelet and cryoprecipitate transfuesd was less in aPRP group than that in control group through four grades（P<0.05）. The amounts of suspended red cells（PLT count<200×10⁹/L）and plasma（PLT count<250×10⁹/L）in aPRP groups were decreased significantly comparing with control groups（P<0.05）. However,there was no significant differences in the transfusion volume of suspended red cells（PLT count≥200×10⁹/L）and plasma（PLT count≥250×10⁹/L）between aPRP and control groups（P>0.05）. Conclusions In order to reduce the use of allogeneic platelets,autologous platelet separation and transfusion technology can be applied to patients with normal platelet count. For patients with platelets count in the range of（100~200）×10⁹/L,autologous platelet separation and transfusion technology should be strongly recommended. It can significantly save blood products.

Key words: Aortic dissection, Autologous platelet separation technology, Platelet count