Research Progress on the Mechanism of Platelet Senescence

doi:10.3969/j.issn.1671-2587.2024.05.022

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (5): 709-714.DOI: 10.3969/j.issn.1671-2587.2024.05.022

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Research Progress on the Mechanism of Platelet Senescence

YANG Huayue, LOU Can, LEI Hang, CAI Xiaohong

Department of Clinical Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025

Received:2024-07-08 Online:2024-10-20 Published:2024-09-20

Abstract

Abstract: In recent years, the mechanisms of platelet aging have garnered increasing attention. With advancements in detection technologies, researchers are now able to study the age stratification of platelets in the peripheral blood of healthy individuals, revealing extensive changes at both the transcriptomic and proteomic levels during the aging process. Pathophysiological studies have further elucidated the critical role of platelets in various diseases, closely associated with age-related changes in platelets. However, the specific characteristics of platelet aging and their precise role in disease development remain to be fully elucidated. Therefore, understanding the physiological characteristics and molecular mechanisms of aging platelets under normal conditions is crucial for research. This review summarizes the transcriptomic and proteomic studies on platelet aging in physiological conditions, as well as the changes in platelet turnover in related diseases, aiming to provide a reference for exploring the relationship between platelet aging and disease development.

Key words: Platelet, Ageing, Clearance mechanism, Transcriptomics, Proteomics, Function

CLC Number:

R457

YANG Huayue, LOU Can, LEI Hang, CAI Xiaohong. Research Progress on the Mechanism of Platelet Senescence[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(5): 709-714.

References

[1] MACHLUS K R,JR ITALIANO J E. The incredible journey:From megakaryocyte development to platelet formation[J]. J Cell Biol,2013,201(6):785-796.
[2] COHEN J A,LEEKSMA C H.Determination of the life span of human blood platelets using labelled diisopropylfluorophosphonate[J]. J Clin Invest,1956,35(9):964-969.
[3] ALLAN H E,HAYMAN M A,MARCONE S,et al.Proteome and functional decline as platelets age in the circulation[J]. J Thromb Haemost,2021,19(12):3095-3112.
[4] ARMSTRONG P C,ALLAN H E,KIRKBY N S,et al.Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs[J]. Blood Adv,2022,6(23):6028-6038.
[5] VERDOIA M,PERGOLINI P,NARDIN M,et al.Impact of aging on platelet reactivity in diabetic patients receiving dual antiplatelet therapy[J]. J Thromb Thrombolysis,2019,48(3):413-421.
[6] MASON K D,CARPINELLI M R,FLETCHER J I,et al.Programmed anuclear cell death delimits platelet life span[J]. Cell,2007,128(6):1173-1186.
[7] TIAN J,CHENG L H,CUI X,et al.Investigating the effect of age on platelet ultrastructure using transmission electron microscopy[J]. Int Wound J,2019,16(6):1457-1463.
[8] VAN DER MEIJDEN P E J,HEEMSKERK J W M. Platelet biology and functions:new concepts and clinical perspectives[J]. Nat Rev Cardiol,2019,16(3):166-179.
[9] PEREIRA J,SOTO M,PALOMO I,et al.Platelet aging in vivo is associated with activation of apoptotic pathways:studies in a model of suppressed thrombopoiesis in dogs[J]. Thromb Haemost,2002, 87(5):905-909.
[10] DEBRINCAT M A,PLEINES I,LEBOIS M,et al.BCL-2 is dispensable for thrombopoiesis and platelet survival[J]. Cell Death Dis,2015,6(4):e1721.
[11] LEBOIS M,JOSEFSSON E C.Regulation of platelet lifespan by apoptosis[J]. Platelets,2016,27(6):497-504.
[12] SOSLAU G,GILES J.The loss of sialic acid and its prevention in stored human platelets[J]. Thromb Res,1982,26(6):443-455.
[13] GERARD JANSEN A J,JOSEFSSON E C,RUMJANTSEVA V,et al. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice[J]. Blood,2012,119(5):1263-1273.
[14] LIANG X,SYED A K,RUSSELL S R,et al.Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance[J]. J Thromb Haemost,2016,14(2):381-386.
[15] MACK J P,MILES J,STOLLA M.Cold-stored platelets:review of studies in humans[J]. Transfus Med Rev,2020,34(4):221-226.
[16] WANG S C,LIU Q,CHENG L H,et al.Targeting biophysical cues to address platelet storage lesions[J]. Acta Biomater,2022,151:118-133.
[17] FIŠAR Z,HROUDOVÁ J,ZVĚŘOVÁ M,et al. Age-dependent alterations in platelet mitochondrial respiration[J]. Biomedicines,2023,11(6):1564.
[18] SMETHURST P A.Aging of platelets stored for transfusion[J]. Platelets,2016,27(6):526-534.[19] DASGUPTA S K,ARGAIZ E R,MERCADO J E,et al. Platelet senescence and phosphatidylserine exposure[J]. Transfusion,2010,50(10):2167-2175.
[20] ZHUANG Y L,REN G J,LI H Y,et al.In vitro properties of apheresis platelet during extended storage in plasma treated with anandamide[J]. Transfus Apher Sci,2014,51(1):58-64.
[21] QUACH M E,CHEN W C,LI R H.Mechanisms of platelet clearance and translation to improve platelet storage[J]. Blood,2018,131(14):1512-1521.
[22] SCHROER A B,VENTURA P B,SUCHAROV J,et al.Platelet factors attenuate inflammation and rescue cognition in ageing[J]. Nature,2023,620(7976):1071-1079.
[23] PARK C,HAHN O,GUPTA S,et al.Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice[J]. Nat Aging,2023,3(9):1067-1078.
[24] THOMPSON C B,LOVE D G,QUINN P G,et al.Platelet size does not correlate with platelet age[J]. Blood,1983,62(2):487-494.
[25] MEZZANO D,HWANG K,CATALANO P,et al.Evidence that platelet buoyant density,but not size,correlates with platelet age in man[J]. Am J Hematol,1981,11(1):61-76.
[26] KO Y J,HUR M,KIM H,et al.Reference interval for immature platelet fraction on Sysmex XN hematology analyzer:a comparison study with Sysmex XE-2100[J]. Clin Chem Lab Med,2015,53(7):1091-1097.
[27] ANGÉNIEUX C,MAÎTRE B,ECKLY A,et al. Time-dependent decay of mRNA and ribosomal RNA during platelet aging and its correlation with translation activity[J]. PLoS One,2016,11(1):e0148064.
[28] BONGIOVANNI D,SANTAMARIA G,KLUG M,et al.Transcriptome analysis of reticulated platelets reveals a prothrombotic profile[J]. Thromb Haemost,2019, 119(11):1795-1806.
[29] HILLE L,LENZ M,VLACHOS A,et al.Ultrastructural, transcriptional,and functional differences between human reticulated and non-reticulated platelets[J]. J Thromb Haemost,2020,18(8):2034-2046.
[30] CLANCY L,BEAULIEU L M,TANRIVERDI K,et al.The role of RNA uptake in platelet heterogeneity[J]. Thromb Haemost,2017,117(5):948-961.
[31] MILLS E W,GREEN R,INGOLIA N T.Slowed decay of mRNAs enhances platelet specific translation[J]. Blood,2017,129(17):e38-e48.
[32] ROWLEY J W,WEYRICH A S.Ribosomes in platelets protect the messenger[J]. Blood,2017,129(17):2343-2345.
[33] WEYRICH A S,SCHWERTZ H,KRAISS L W,et al.Protein synthesis by platelets:historical and new perspectives[J]. J Thromb Haemost,2009,7(2):241-246.
[34] ALLAN H E,VADGAMA A,ARMSTRONG P C,et al.What can we learn from senescent platelets,their transcriptomes and proteomes?[J]. Platelets,2023,34(1):2200838.
[35] HUANG J N,ZHANG P Y,SOLARI F A,et al.Molecular proteomics and signalling of human platelets in health and disease[J]. Int J Mol Sci,2021,22(18):9860.
[36] HANDTKE S,STEIL L,PALANKAR R,et al.Role of platelet size revisited-function and protein composition of large and small platelets[J]. Thromb Haemost,2019, 119(3):407-420.
[37] KRAMER P A,RAVI S,CHACKO B,et al.A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes:implications for their use as bioenergetic biomarkers[J]. Redox Biol,2014,2:206-210.
[38] YE T,SHI H X,PHAN-THIEN N,et al.The key events of Thrombus formation: platelet adhesion and aggregation[J]. Biomech Model Mechanobiol, 2020,19(3):943-955.
[39] ASSINGER A,VOLF I,SCHMID D.A novel,rapid method to quantify intraplatelet calcium dynamics by ratiometric flow cytometry[J]. PLoS One,2015,10(4): e0122527.
[40] AJANEL GOMEZ A,DENORME F,PORTIER I,et al.Platelet mitochondria calcium uniporter regulates ITAM-dependent platelet activation and signaling[J]. Blood,2023,142:1187.
[41] CHO J,TJOTA M,GUTIERREZ J,et al.Analysis of platelet alpha and dense granule release using small volumes of blood[J]. Blood,2019,134(Supplement_1): 2342.
[42] AL-NAJJAR B O,ABBAS M A,SIBAI O A,et al. QSAR,structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y₁₂) antagonist[J]. RSC Med Chem,2023,14(2):239-246.
[43] KEUREN J F,CAUWENBERGHS S,HEEREMANS J,et al.Platelet ADP response deteriorates in synthetic storage media[J]. Transfusion,2006,46(2):204-212.
[44] MELCHINGER H,JAIN K,TYAGI T,et al.Role of platelet mitochondria:life in a nucleus-free zone[J]. Front Cardiovasc Med,2019,6:153.
[45] GU S X,DAYAL S.Redox mechanisms of platelet activation in aging[J]. Antioxidants (Basel),2022,11(5):995.
[46] DAVIZON-CASTILLO P,MCMAHON B,AGUILA S,et al.TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging[J]. Blood,2019,134(9):727-740.
[47] PRICE J,LORD J M,HARRISON P.Inflammaging and platelet hyperreactivity:a new therapeutic target?[J]. J Thromb Haemost,2020,18(1):3-5.
[48] PAGE M J,BESTER J,PRETORIUS E.The inflammatory effects of TNF-α and complement component 3 on coagulation[J]. Sci Rep,2018,8(1):1812.
[49] BODROVA V V,SHUSTOVA O N,KHASPEKOVA S G, et al.Laboratory markers of platelet production and turnover[J]. Biochemistry,2023,88(Suppl 1): S39-S51.
[50] ALLAN H E,VADGAMA A,ARMSTRONG P C,et al.Platelet ageing:a review[J]. Thromb Res,2023,231:214-222.
[51] WELDER D,JEON-SLAUGHTER H,ASHRAF B, et al.Immature platelets as a biomarker for disease severity and mortality in COVID-19 patients[J]. Br J Haematol,2021,194(3):530-536.
[52] VERDOIA M,NARDIN M,ROLLA R,et al.Immature platelet fraction and the extent of coronary artery disease:a single centre study[J]. Atherosclerosis, 2017,260:110-115.
[53] HIMMELFARB J,HOLBROOK D,MCMONAGLE E,et al.Increased reticulated platelets in dialysis patients[J]. Kidney Int,1997,51(3):834-839.
[54] PERL L,MATATOV Y,KORONOWSKI R,et al.Prognostic significance of reticulated platelet levels in diabetic patients with stable coronary artery disease[J]. Platelets,2020,31(8):1012-1018.
[55] MIJOVIC R,KOVACEVIC N,ZARKOV M,et al.Reticulated platelets and antiplatelet therapy response in diabetic patients[J]. J Thromb Thrombolysis, 2015,40(2):203-210.
[56] BERNLOCHNER I,GOEDEL A,PLISCHKE C,et al.Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome[J]. Eur Heart J,2015,36(45):3202-3210.
[57] ANGIOLILLO D J,BERNARDO E,SABATÉ M, et al.Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease[J]. J Am Coll Cardiol,2007, 50(16):1541-1547.
[58] STRATZ C,BÖMICKE T,YOUNAS I,et al. Comparison of immature platelet count to established predictors of platelet reactivity during thienopyridine therapy[J]. J Am Coll Cardiol,2016,68(3):286-293.
[59] IBRAHIM H,NADIPALLI S,DELAO T,et al.Immature platelet fraction (IPF) determined with an automated method predicts clopidogrel hyporesponsiveness[J]. J Thromb Thrombolysis,2012,33(2):137-142.
[60] POSCABLO D M,WORTHINGTON A K,SMITH-BERDAN S,et al. An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis[J]. Cell,2024,187(12):3090-3107.e21.

Research Progress on the Mechanism of Platelet Senescence

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