Abstract: Objectives To investigate the levels of serum uric acid(SUA) and lipids in first-time donors from Guangdong and Guangxi provinces and its risk factors. Methods A total of 11485 first-time donors in Guangxi (Bama and Pingguo) and coastal areas in Guangdong (Suixi and Lianjiang) between April 2021 and August 2022 by completely random sampling were randomly selected. The levels of SUA, high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), total cholesterol (TC) and triglyceride (TG) were analyzed. Results Among the 11 485 first-time donors, the proportion of abnormal SUA was 22% and dyslipidemia rate was 57.6%. The levels of UA, LDL-C, TC and TG were significantly correlated with age (UA: r_all=-0.291, r_male=-0.138, r_female=-0.170; r_LDL-C=0.300, r_TC=0.340, r_TG=0.234; P<0.001). The levels of SUA, HDL-C, LDL-C, TC and TG were significantly correlated with their BIM (UA: r_all=0.201, r_male=0.243, r_female=0.241; r_HDL-C=-0.273, r_LDL-C=0.316, r_TC=0.275, r_TG=0.335; P<0.001). There were significant differences in SUA and lipids (HDL-C, LDL-C, TC, TG) among first-time donors in different plasma station (P<0.001). There were significant differences in the levels of HDL-C, LDL-C and TC among different blood types (P<0.001). The levels of SUA and TG in males were significantly higher than those in females (UA: 366 μmol/L vs 262 μmol/L, TG: 1.4 mmol/L vs 1.4 mmol/L, P<0.001). The levels of HDL-C and TC in females were significantly higher than those in males (HDL-C: 1.1 mmol/L vs 0.9 mmol/L, TC: 3.7 mmol/L vs 3.6 mmol/L, P<0.001). There were significant differences in SUA, HDL-C and TC levels between Han nationality and ethnic minorities (P<0.001). The rates of abnormal SUA and dyslipidemia among different regions, genders, blood types and nationalities (P<0.001). The plasma station, dyslipidemia, sex, age, weight and height of donors were independent risk factors (P<0.001). The plasma station, abnormal SUA, sex, blood type, age, weight and height were independent risk factors for dyslipidemia (P<0.001). The plasma station, sex, weight and height were independent risk factors of abnormal SUA and dyslipidemia (P<0.001). Conclusion The abnormal SUA and dyslipidemia of first-time donors in Guangdong and Guangxi areas were higher. The abnormal rate of the above indicators in coastal areas of Guangdong was higher than that in inland areas of Guangxi. It is speculated that this may be related to the different eating habits of the two places.

Key words: First-time plasma donors, Serum uric acid, Serum lipid, Abnormal SUA, Dyslipidemia