Research Progress on the Regulation of Platelet Coagulation Function by Traditional Chinese Medicine

doi:10.3969/j.issn.1671-2587.2025.01.020

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (1): 140-144.DOI: 10.3969/j.issn.1671-2587.2025.01.020

Research Progress on the Regulation of Platelet Coagulation Function by Traditional Chinese Medicine

ZHONG Cheng, LUO zhanpeng

Chongqing Blood Center, Chongqing 400052

Received:2024-08-26 Published:2025-02-25

Abstract

Abstract: Platelets play an important role in blood aggregation and thrombosis, and their abnormal function may lead to thrombotic diseases. Traditional Chinese medicine (TCM), as an important component of traditional medicine, has been widely used since ancient times to regulate blood function. This paper reviews the recent studies on the effects of TCM on platelet coagulation function. Firstly, the effects of TCM on platelet adhesion, vascular wall affinity, platelet aggregation and release were discussed, including the regulation of ADP-mediated platelet aggregation and calcium influx. Secondly, the research status of some TCM used in the treatment of diseases related to platelet dysfunction was summarized. Finally, the future development direction of the combination of TCM and modern medicine was discussed, emphasizing the potential of TCM in the treatment of thrombotic diseases and the necessity of further research.

Key words: Traditional Chinese medicine, Platelet function, Thrombus

CLC Number:

R457R28

ZHONG Cheng, LUO zhanpeng. Research Progress on the Regulation of Platelet Coagulation Function by Traditional Chinese Medicine[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(1): 140-144.

References

[1] HOLINSTAT M.Normal platelet function[J].Cancer Metastasis Rev,2017,36(2):195-198.
[2] PICKER S M.In-vitro assessment of platelet function[J].Transfus Apher Sci,2011,44(3):305-319.
[3] MONROE D M,HOFFMAN M,ROBERTS H R.Platelets and thrombin generation[J].Arterioscler Thromb Vasc Biol,2002,22(9):1381-1389.
[4] LI X A,GUO T T,FENG Q,et al.Progress of Thrombus formation and research on the structure-activity relationship for antithrombotic drugs[J].Eur J Med Chem,2022,228:114035.
[5] GRESELE P,GUGLIELMINI G,DEL PINTO M,et al.Peripheral arterial disease has a strong impact on cardiovascular outcome in patients with acute coronary syndromes:from the START antiplatelet registry[J].Int J Cardiol,2021,327:176-182.
[6] SHATTIL S J.Function and regulation of the beta 3 integrins in hemostasis and vascular biology[J].Thromb Haemost,1995,74(1):149-155.
[7] WANG Y C,CHEN W Q,ZHOU J,et al.Nitrate metabolis m and ischemic cerebrovascular disease:a narrative review[J].Front Neurol,2022,13:735181.
[8] SIKORA J,KARCZMARSKA-WÓDZKA A,BUGIEDA J,et al.The importance of platelets response during antiplatelet treatment after ischemic stroke-between benefit and risk:a systematic review[J].Int J Mol Sci,2022,23(3):1043.
[9] LI H Q,WEI J J,XIA W,et al.Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage:a systematic review and meta-analysis[J].Acta Pharmacol Sin,2015,36(6):659-675.
[10] SUN W,ZHANG L S,FANG Z R,et al.Shuxuetong injection and its peptides enhance angiogenesis after hindlimb ischemia by activating the MYPT1/LIMK1/Cofilin pathway[J].J Ethnopharmacol,2022,292:115166.
[11] LI D,LI Y J,YANG S J,et al.Mechanism and potential target of blood-activating Chinese botanical drugs combined with anti-platelet drugs:prevention and treatment of atherosclerotic cardiovascular diseases[J].Front Pharmacol,2022,13:811422.
[12] AYATOLLAHI H,JAVAN A O,KHAJEDALUEE M,et al.Effect of Crocus sativus L.(saffron)on coagulation and anticoagulation systems in healthy volunteers[J].Phytother Res,2014,28(4):539-543.
[13] ZHANG Q C,ZHAO Y,BIAN H M.Anti-thrombotic effect of a novel formula from Corni fructus with malic acid,succinic acid and citric acid[J].Phytother Res,2014,28(5):722-727.
[14] YASIN M,HUSSAIN JANBAZ K,IMRAN I,et al.Pharmacological studies on the antispasmodic, bronchodilator and anti-platelet activities of Abies webbiana[J].Phytother Res,2014,28(8):1182-1187.
[15] ZHANG H,TANG W W,WANG S,et al.Tetramethylpyraz ine inhibits platelet adhesion and inflammatory response in vascular endothelial cells by inhibiting P38 MAPK and NF-κB signaling pathways[J].Inflammation,2020,43(1):286-297.
[16] NAM G S,LEE K S,NAM K S.Morin hydrate inhibits platelet activation and clot retraction by regulating integrin α_IIbβ₃,TXA₂,and cAMP levels[J].Eur J Pharmacol,2019,865:172734.
[17] SHEN X,WU Y Y,CHEN P,et al.Anti-platelet aggregation activities of different grades of Angelica sinensis and their therapeutic mechanisms in rats with blood deficiency:insights from metabolomics and lipidomics analyses[J].Front Pharmacol,2023,14:1230861.
[18] KEIHANIAN F,SAEIDINIA A,BAGHERI R K,et al.Curcumin,hemostasis,thrombosis,and coagulation[J].J Cell Physiol,2018,233(6):4497-4511.
[19] TABESHPOUR J,HASHEMZAEI M,SAHEBKAR A.The regulatory role of curcumin on platelet functions[J].J Cell Biochem,2018,119(11):8713-8722.
[20] YANG R P,ZHOU Y J,SONG W,et al.Pharmacological actions of neferine in the modulation of human platelet function[J].Eur J Pharmacol,2019,862:172626.
[21] ZHOU Y J,XIANG J Z,YUAN H J,et al.Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates[J].Thromb Res,2013,132(2):202-210.
[22] SON Y M,JEONG D H,PARK H J,et al.The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation[J].J Ginseng Res,2017,41(1):96-102.
[23] ZHOU Q,JIANG L,XU C H,et al.Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis[J].Thromb Res,2014,133(1):57-65.
[24] 万蒞,易蕾,王红.酸枣仁皂苷A的抗血小板聚集活性研究[J].中国现代应用药学,2018,35(10):1514-1516.
[25] CAI X X,CHEN Z,PAN X K,et al.Inhibition of angiogenesis,fibrosis and thrombosis by tetramethylpyrazine:mechanisms contributing to the SDF-1/CXCR4 axis[J].PLoS One,2014,9(2):e88176.
[26] ZHANG Y,XIN G,ZHOU Q L,et al.Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza bunge via network pharmacology:unveiling their roles in the modulation of platelet activation and Thrombus formation[J].Toxicol Appl Pharmacol,2024,484:116871.
[27] YU C,QI D,LIAN W,et al.Effects of danshensu on platelet aggregation and thrombosis:in vivo arteriovenous shunt and venous thrombosis models in rats[J].PLoS One,2014,9(11):e110124.
[28] XUE Y J,ZHANG L Y,ZHANG L S,et al.Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk[J].Phytomedicine,2022,104:154271.
[29] FAN H J,LI M,YU L,et al.Effects of Danhong Injection on platelet aggregation in hyperlipidemia rats[J].J Ethnopharmacol,2018,212:67-73.
[30] SARKAR C,QUISPE C,JAMADDAR S,et al.Therapeutic promises of ginkgolide A:a literature-based review[J].Biomedecine Pharmacother,2020,132:110908.
[31] LI R H,XIA Z M,LI B,et al.Advances in supercritical carbon dioxide extraction of bioactive substances from different parts of Ginkgo biloba L[J].Molecules,2021,26(13):4011.
[32] GROENEWEGEN W A,HEPTINSTALL S.A comparison of the effects of an extract of feverfew and parthenolide,a component of feverfew,on human platelet activity in-vitro[J].J Pharm Pharmacol,1990,42(8):553-557.
[33] SAHLER J,BERNARD J J,SPINELLI S L,et al.The Feverfew plant-derived compound,parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition[J].Thromb Res,2011,127(5):426-434.
[34] MAYANGLAMBAM A,DANGELMAIER C A,THOMAS D,et al.Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2[J].Platelets,2010,21(3):211-220.
[35] JIN Y R,YU J Y,LEE J J,et al.Antithrombotic and antiplatelet activities of Korean red ginseng extract[J].Basic Clin Pharmacol Toxicol,2007,100(3):170-175.
[36] 李铭铭,罗云梅,李映莹,等.异钩藤碱抗血小板聚集和释放作用的研究[J].河南医学研究,2023,32(17):3094-3097.
[37] CHATTERJEE M,EHRENBERG A,TOSKA L M,et al.Molecular drivers of platelet activation:unraveling novel targets for anti-thrombotic and anti-thrombo-inflammatory therapy[J].Int J Mol Sci,2020,21(21):7906.
[38] BURNOUF T,WALKER T L.The multifaceted role of platelets in mediating brain function[J].Blood,2022,140(8):815-827.
[39] MARTIN S S,ADAY A W,ALMARZOOQ Z I,et al.2024 heart disease and stroke statistics:a report of US and global data from the American heart association[J].Circulation,2024,149(8):e347-e913.
[40] IRFAN M,KIM M,RHEE M H.Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases[J].J Ginseng Res,2020,44(1):24-32.
[41] LUO B Y,JIANG J L,FANG Y F,et al.The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases:from molecular mechanisms to clinical applications[J].Pharmacol Res,2020,159:105031.
[42] 路丽娟,陈晓丹,周雪菲.三七总皂苷对冠心病心绞痛患者血浆内皮素-1和血小板功能的影响价值[J].内蒙古中医药,2024,43(3):65-66.
[43] XU C C,WANG W W,WANG B,et al.Analytical methods and biological activities of Panax notoginseng saponins:recent trends[J].J Ethnopharmacol,2019,236:443-465.
[44] ZOU J B,ZHANG X F,WANG J,et al.The therapeutic efficacy of Danhong injection combined with percutaneous coronary intervention in acute coronary syndrome:a systematic review and meta-analysis[J].Front Pharmacol,2018,9:550.
[45] BI C,LI P L,LIAO Y,et al.Pharmacodynamic effects of Dan-Hong injection in rats with blood stasis syndrome[J].Biomedecine Pharmacother,2019,118:109187.
[46] 周建峰,张克清,杨志洋,等.芪参祛瘀方治疗缺血性中风气虚血瘀证患者的临床疗效及对其血清神经细胞因子、血小板聚集功能的影响[J].世界中西医结合杂志,2023,18(12):2493-2497.

Research Progress on the Regulation of Platelet Coagulation Function by Traditional Chinese Medicine

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