New Progress on the Molecular Mechanism of Sema7a Protein

doi:10.3969/j.issn.1671-2587.2025.02.014

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (2): 234-246.DOI: 10.3969/j.issn.1671-2587.2025.02.014

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New Progress on the Molecular Mechanism of Sema7a Protein

LAI Dongdi^1,2,3, ZHONG Minglu^1,2,3, DONG Han^1,2, PENG Weikang^1,2,3, WEI Yaming^1,2,3, YUAN Zhaohu^1,2,3

¹Department of Blood Transfusion, Guangzhou First Peoples Hospital, Guangzhou, 510180;
²Guangdong Engineering Research Centre of Precise Transfusion, Guangzhou, 510180;
³Research institute of Blood Transfusion and Hematology, Guangzhou Medical University, 510180

Received:2024-12-23 Online:2025-04-20 Published:2025-04-17

Abstract

Abstract: Sema7a protein, a member of the semaphorin protein family, also known as CDw108 or JMH antigen, is a blood group antigen on the surface of erythrocyte membrane. It's a glycosylphosphatidylinositol (GPI)-anchored glycoprotein widely expressed on the cell membranes of various tissues throughout the body. The Sema7a protein can be cleaved from cell membrane by various physical and chemical factors, such as enzyme, blood shear force and hypoxia. The Sema7a protein on the surface of erythrocyte membrane is the main source of free Sema7a in vivo. The Sema7a protein can bind to two known receptors, integrin or PlexinC1 (PlexinC1), or in a free form to participate in various biological activities throughout the body, and plays an important role in cell differentiation, nerve signal transduction, immune response, inflammation regulation, and tumor progression. This review summarizes the mechanisms of Sema7a protein involvement in the occurrence and development of different diseases based on the classification of systemic disease.

Key words: Sema7a, JMH antigen, Integrin, Plexin C1

CLC Number:

Q516

LAI Dongdi, ZHONG Minglu, DONG Han, PENG Weikang, WEI Yaming, YUAN Zhaohu. New Progress on the Molecular Mechanism of Sema7a Protein[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 234-246.

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New Progress on the Molecular Mechanism of Sema7a Protein

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