Analysis of Screening for HBV, HCV and HIV Infections in Patientswith Secondary Immunodeficiency

doi:10.3969/j.issn.1671-2587.2025.04.007

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (4): 478-483.DOI: 10.3969/j.issn.1671-2587.2025.04.007

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Analysis of Screening for HBV, HCV and HIV Infections in Patientswith Secondary Immunodeficiency

ZHANG Qi¹, GUI Rong⁶, LIU Juan¹¹, ZHANG Jun¹, ZHOU Lujie¹, LIU Fenghua², LV Xianping⁹, HU Junhua³, ZHOU Jun¹¹, MA Xinghuan¹¹, WANG Peng⁴, YANG Jiangcun⁵, DU Chunhong⁷, LI Xiying⁸, QIN Li¹⁰, GONG Jiwu³, XIA Rong¹

¹Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040;
²Department of Transfusion Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin 150007;
³Department of Blood Transfusion, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730;
⁴Department of Transfusion Medicine, Peking University First Hospital, Beijing 100034;
⁵Department of Transfusion Medicine, Shaanxi Provincial People's Hospital, Xi'an 710068;
⁶Department of Transfusion Medicine, the Third Xiangya Hospital of Central South University, Changsha 410017;
⁷Department of Transfusion Medicine, Tianjin Medical University General Hospital, Tianjin 300052;
⁸Department of Transfusion Medicine, Cancer Hospital Chinese Academy of Medical Sciences, Beijing 100020;
⁹Department of Transfusion Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052;
¹⁰Department of Transfusion Medicine, West China Hospital, Sichuan University, Chengdu 610041;
¹¹Research Center for Technologies in Nucleic Acid-Based Diagnostics and Therapeutics, Changsha 410000

Received:2024-12-11 Published:2025-08-22

Abstract

Abstract: Objective To investigate the infection status of HBV, HCV, and HIV in patients with secondary immunodeficiencyby a multicenter analysis. Methods Blood samples of preoperative or pre-transfusional patients were collected from ten medical institutions for HBV, HCV and HIV detection from July 2021 to December 2021 and from January 2023 to June 2023. Results A total of 25 927 samples were collected in this study, including 4 609 (17.78%) from patients with secondary immunodeficiency, comprising 19 patients on hemodialysis, 44 patients undergone organ transplantation, and 4 546 patients with malignant tumors. During the same period, 21 318 general patients (82.22%) were also tested. Thepositive rates of HBV, HCV and HIV in secondary immunodeficiency patients were 7.29%, 0.28% and 0.09% respectively, while thepositive rates of HBV, HCV and HIV were 5.40%, 0.32% and 0.05% in general patientsrespectively. Moreover, there was significant difference in the positive detection rate of HBV assessed by the two methods. Among patients with secondary immunodeficiency, the detection rate of serological negativity and nucleic acid positivity was 1.04% (48 cases), whilethe detection rate of serological positivity and nucleic acid negativity was 0.52% (24 cases). Among general patients, the detection rate of serological negativity and nucleic acid positivity was 0.82% (174 cases), andthe detection rate of serological positivity and nucleic acid negativity was 0.42% (89 cases). Conclusion The risk of HBV infection insecondary immunodeficiency patients was higher than that general patients. Nucleic acid test has the advantage on increasing the detection rate of HBV in immunodeficient patients before surgery and blood transfusion.

Key words: Secondary immunodeficiency, Nucleic acid test, Infectious disease screenings, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus

CLC Number:

R593.3

ZHANG Qi, GUI Rong, LIU Juan, ZHANG Jun, ZHOU Lujie, LIU Fenghua, LV Xianping, HU Junhua, ZHOU Jun, MA Xinghuan, WANG Peng, YANG Jiangcun, DU Chunhong, LI Xiying, QIN Li, GONG Jiwu, XIA Rong. Analysis of Screening for HBV, HCV and HIV Infections in Patientswith Secondary Immunodeficiency[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(4): 478-483.

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Analysis of Screening for HBV, HCV and HIV Infections in Patientswith Secondary Immunodeficiency

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