Results of 10173 Hepatitis B Specimens Detected by Serologic Test and Nucleic Acid Testing

doi:10.3969/j.issn.1671-2587.2020.06.006

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2020, Vol. 22 ›› Issue (6): 583-586.DOI: 10.3969/j.issn.1671-2587.2020.06.006

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Results of 10173 Hepatitis B Specimens Detected by Serologic Test and Nucleic Acid Testing

LIU Hai-ting, DENG Zhi-hua, CAI Dan, et al

Blood Transfusion Department,The Third Xiangya Hospital of Central South University,Hunan 410013

Received:2020-09-09 Online:2020-12-20 Published:2021-01-18

Abstract

Abstract: Objective To discuss the detection of hepatitis B virus (HBV) nucleic acid testing (NAT) in HBsAg-negative specimens.Methods A total of 10 173 results of HBV serology test and nucleic acid test from 23 hospitals in China between Oct 2019 and Jun 2020 were collected.HBsAg-negative specimens were Firstly included,and results of serum HBV DNA qualitative test were analyzed.Positive HBV DNA specimens were further included,and tested for serological marker HBsAb,HBeAg,HBeAb and HBcAb.The overall distribution of Ct value intervals and serological marker patterns were analyzed.Results 254(2.77%)of 9 186 HBsAg negative cases included were HBV DNA positive.There were eight serological patterns of HBV markers in 168 HBV DNA positive.166(98.81%) of those patients were occult hepatitis B infection(OBI).Conclusion HBV NAT could detect a certain percentage of HBV patients in HBsAg-negative specimens,especially for OBI patients.HBV NAT screening is important to detect OBI to avoid missing cases.

Key words: Hepatitis B virus nucleic acid testing, HBsAg, Hepatitis B serological markers, Occult hepatitis B infection

CLC Number:

R512.62

LIU Hai-ting, DENG Zhi-hua, CAI Dan, et al. Results of 10173 Hepatitis B Specimens Detected by Serologic Test and Nucleic Acid Testing[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(6): 583-586.

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Results of 10173 Hepatitis B Specimens Detected by Serologic Test and Nucleic Acid Testing

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