Abstract: Objective To investigate the clinical significance of quantitative detection of HBsAg and HBV DNA in the patients with chronic hepatitis B and liver cirrhosis. Methods The levels of serum HBsAg and HBV DNA were retrospectively analyzed in 74 patients with chronic active hepatitis B without liver cirrhosis （group A）,39 cases of cirrhosis at compensated stage （group B）,and 39 cases at decompensated stage （group C）. Results The loads of HBsAg and HBV DNA gradually decreased with the disease exacerbation（P<0.05）; the quantitative levels of HBsAg and HBV DNA were closely correlated in patients of the three group（r=0.614,P<0.001）. The level of HBsAg,however,did not show any correlation with that of HBV DNA in the patients of groups B（r=0.267,P=0.101） and C（r=0.232,P=0.155）,in which the levels of HBsAg and HBV DNA exhibited a negative correlation with the severity of liver cirrhosis. Conclusion sThe level of HBsAg gradually decreases with the severity of liver cirrhosis in the patients with chronic hepatitis B,compensated cirrhosis,and decompensated cirrhosis. The load of HBsAg is positively correlated with that of HBV DNA.

Key words: HBsAg, HBV DNA, Chronic hepatitis B, Liver cirrhosis