Abstract: Objective To study HBsAg and HBV-DNA in the patients with chronic hepatitis B （CHB）,cirrhosis and hepatocellular carcinoma. Methods Of 200 CHB patients enrolled in the study within four years,116 cases of CHB,74 cases of liver cirrhosis,and 10 cases of primary liver cancer were detected for HBV makers with chemiluminescence and for HBV-DNA with PCR. Results In HBsAg and HBV DNA quantification of the three groups,a significant difference was seen in HBV makers that presented positive HBsAg,HBeAg,and anti-HBc（P<0.05）. Conclusion Patients with CHB may exhibit the shifted level of HBV makers and the decreased levels of HBsAg and HBV-DNA with the disease progressed,which may indicate a trend of the development of hepatic cirrhosis or liver carcinogenesis.

Key words: Chronic hepatitis B, Liver cirrhosis, Primary liver cancer