Abstract: Objective To investigate the application value of Golgi glycoprotein 73（GP73）in the diagnosis of chronic liver diseases. Methods The peripheral serum samples were collected from patients with hepatocellular carcinoma （HCC）（n=91），hepatocirrhosis（n=217），hepatitis（n=230），and healthy control group（n=62），and the serum GP73 and AFP were determined by Elisa and electrochemiluminescence . Methods respectively. Then the specificity and sensitivity were statistically analyzed. Results The level of serum GP73 was the highest in patients with HCC，followed by hepatocirrhosis group，hepatitis group and healthy control group（P<0.05）. In the diagnosis of HCC，the sensitivity and specificity of GP73 was 65.9% and 79.5%，respectively，and the sensitivity and specificity of AFP for HCC were 61.5% and 74.6%，respectively. While combined measurement of AFP and GP73 increased the sensitivity and specificity to 84.6% and 90.1% respectively. Moreover，in patients with HCC，the level of AFP was correlated with serum DBIL and AST，while GP73 level was associated with TBIL，DBIL，TBA，ALT and AST. Conclusion The sensitivity and specificity of GP73 were high enough for liver cancer screening，while combination measurement of GP73 and AFP would further improve clinical application value in diagnosis of hepatocellular carcinoma.

Key words: Hepatocellular carcinoma , Golgi protein 73, Alpha fetal protein