Abstract: Objective To investigate the effect of information system application in nursing safety transfusion practice and experience in nursing management. Methods The hospital quality control team members used information query system to monitor the implementation of blood transfusion. The blood transfusion system used as an evaluation criterion，and to find the problems in the transfusion process. Results Before and after the quality control，the blood transfusion standard execution time，the infusion time，and the patrol time was statistically significant different. Conclusion The information system applied to blood transfusion nursing safety management can improve the quality of nursing，and was convenient to the nursing quality control.

Key words: Blood transfusion management , Information system , Nursing safety