Abstract: Objective To evaluate the prognostic value of TSGF,SCC-Ag and CA125 in peripheral blood of patients with cervical cancer before chemotherapy.Methods 70 patients with cervical cancer diagnosed with I-II were enrolled in our hospital from January 2013 to January 2014 and were followed up for 3 years after the end of treatment. The recurrence of tumor was recorded and the patients were treated with different prognosis. The expression levels of TSGF,SCC-Ag and CA125 in peripheral blood were detected before and after treatment. The prognostic value of these indexes was analyzed.Results The expression levels of TSGF,SCC-Ag and CA125 in peripheral blood of patients without recurrence（54.63±12.35 U/mL、2.42±0.60 μg/L、27.28±12.28 U/mL） were significantly lower than those in patients with relapse after three years（78.29±18.29 U/mL、3.89±1.25 μg/L、36.43±13.05 U/mL）（P<0.05）.The expression of TSGF,SCC-Ag and CA125 in peripheral blood was positively correlated with the risk of recurrence within three years after treatment （r=0.535,r=0.329,r= 0.744,P<0.05） by Spearman correlation analysis. Further ROC analysis showed that the sensitivity,specificity and accuracy of TSGF,SCC-Ag and CA125 expression in cervical cancer were significantly higher than those in cervical cancer before and after chemotherapy.Conclusion The level of TSGF,SCC-Ag and CA125 in peripheral blood of patients with early cervical cancer before chemotherapy can be used as one of the indicators of prognosis evaluation.

Key words: Tumor-specific growth factor, Carbohydrate antigen-125, Phosphorus cell carcinoma antigen Cervical cancer