Abstract: Objective To understand the carbohydrate antigen 153 （carbohydrate antigen 153,CA153） and placental growth factor（placental growth factor,PLGF） level in placental abruption maternal serum,and to explore its clinical significance.Methods Collected in March 2014 to August 2017 to shenzhen baoan district people's hospital obstetric delivery of 107 cases of placental abruption maternal as study group,120 cases of normal pregnant women as control group,DXI800 full automatic immune luminescence analysis and enzyme-linked immunosorbent assay （enzyme linked immunosorbent assay,ELISA） maternal prenatal and postnatal three months was detected in concentration of serum CA153 and PLGF,and analyze whether there is a difference between the two sets of results.Results Study group antenatal concentration of serum CA153 was（119.32±37.25）U/mL,significantly higher than the control group of（41.86±19.07）U/mL,difference was statistically significant （t=8.152,P<0.05）,while PLGF concentration was（79.06±15.85）pg/mL,significantly lower than the control group of（132.37±45.26）pg/mL,difference was statistically significant（t=6.974,P<0.05）; In the three months after delivery,the concentrations of CA153 andPLGF in the maternal serum of the study group were（43.92±21.35）U/mL and（121.52±42.67）pg/mL,There was no statistically significant difference between the control group and the control group （t=1.038~1.203,P>0.05）.Conclusion Concentration of CA153 in the prenatal serum of placental abruption was significantly higher,and concentration of PLGF decreased significantly,and thepostpartum recovery was normal. Therefore,the prenatal process of CA153 and PLGF detection has a certain prediction value for the diagnosis of placental abruption,which is worth extending the application.

Key words: Carbohydrate antigen 153, Placental growth factor, Placental abruption, Express, Meaning