Abstract: Objective To explore the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） on postoperative infections following fractures. Methods A total of one hundred and eighty-seven patients with fractures treated in our hospital were divided into infection group （thirty-four cases） and non-infection group （one hundred and fifty-three cases） according to the infection standard,5 mL of veinal blood was collected 1 day before operation,immediate postoperative and 24 h after operation,respectively. The value of ESR was detected by Westergren method,the levels of CRP were measured by immunoturbidimetry assay,the level of PCT was detected by chemiluminescence immunoassay,and the levels of sTREM-1 were measured by enzyme linked immunosorbent assay. The diagnostic value of ESR,CRP,PCT,sTREM-1 for postoperative infections following fractures was performed by receiver operating curve （ROC）. Results Compared to the 1 day before operation,the levels of ESR,CRP,PCT,sTREM-1 in the infection group and non-infection group constantly increasing,there was significant difference between different time points （P﹤0.05）. The levels of ESR,CRP,PCT,sTREM-1 in the infection group were markly higher than that in the non-infection group,the difference between groups was significantly （P﹤0.05）. On the 1 day before operation,the accuracy of ESR,CRP,PCT,sTREM-1 for postoperative infections all were lower （all AUC﹤0.7）. At the moment of immediate postoperative,the AUC of PCT （0.951） higher than ESR （0.830）,CRP （0.738） and sTREM-1 （0.840）. On the 24 h after operation,the AUC of sTREM-1 （0.920） higher than ESR （0.731）,CRP （0.822） and PCT （0.780）. Conclusion Serum PCT can be used as an index for the early diagnosis of postoperative infections following fractures,while sTREM-1 can be used as an index for disease severity and course of infections.

Key words: Infections, Erythrocyte sedimentation rate, C-reactive protein, Procalcitonin, Soluble triggering receptor expressed on myeloid cells-1