Abstract: Objective To investigate the value of clinical applications of the combined detection of procalcitonin（PCT）,fibrin and fibrinogen degradation products（PDP）and C-reactive protein（CRP）in junior patients with sepsis. Methods Samples were collected from 33 patients with sepsis,and 35 common infectious patients in pediatrics and intense care unit（ICU）. Thirty five healthy children were chosen as the control. All specimens were harvested from March 2015 to June 2016. PCT was measured by double-antibody sandwich chemiluminescence immunoassay,FDP and CRP were measured by immunoturbidimetry,respectively. Results The levels of PCT,FDP and CRP in sepsis group were obviously higher than those in common infectious group and the control group,the differences were statistically significant（P<0.05）. CRP level was higher in common infectious group（P<0.05）,no difference was noted of PCT and FDP（P>0.05）. Moreover,with the risk of mortality in emergency department sepsis （MEDS）increase,the levels of all items tested were elevated（P<0.05）. Conclusion PCT,FDP and CRP are important markers during infection. A combined detection of the three markers has a great value in predicting the disease progression in children sepsis.

Key words: Procalcitonin, Fibrin and fibrinogen degradation products, C-reactive protein, Sepsis