Abstract: Objective To observe the clinical value of the plasma procalcitonin （PCT） and C-reactive protein （CRP） in guidance of the rational antibiotic treatment in children with respiratory tract infection. Methods A total of 248 cases of respiratory tract infections were selected in the hospital from August 2013 to February 2016. The patients were randomly divided into control group and observation group,with 124 cases in each. The control group was given antibiotic treatments monitored by CRP testing,while the observation group received the treatments supervised by both CRP and PCT tests. Results No significant difference was seen of the duration of fever,cough and lung rales between the two groups （P>0.05）. However,the durations of antibiotic use and hospital stay were obviously shortened in the observation group than in the control （P<0.05） with a notably decreased frequency of antibiotic uses （P<0.05）. Conclusion Combination of CRP with PCT test may help reduce the frequency and duration of antibiotic uses and avoid double-infection of post-treatment through monitoring the efficacy of the drugs in the children with pulmonary infections .

Key words: Procalcitonin, Antibiotic, Respiratory tract infection