Abstract: ObjectiveTo investigate the current status of non-fermentative bacteria infection and antibiotic resistance in the hospital from 2012 to 2014, in order to provide reference for reasonable clinical utilization．MethodsThe distribution and drug resistance of non-fermentative bacteria which were collected from specimens of hospitalized patients from 2012 to 2014 were retrospectively analyzed. ResultsA total of 3997 strains of non-fermentative bacteria were harvested, the top three species include 1794 strains of Pseudomonas aeruginosa (44.9%), 1674 strains of Acinetobacter baumannii(41.9%) and 252 strains of Stenotrophomonas maltophilia (6.3%). The source of non-fermentative bacteria specimen were mainly sputum (78.61%), secretions and pus (11.23%) in the departments of intensive care unit, respiration, neurosurgery and geriatrics. Drug sensitivity test results showed that Pseudomonas aeruginosa to amikacin, ciprofloxacin and ofloxacin were relatively sensitive, with the rate of resistance to < 2 0%. However, a high percentages of drug resistance to hydrocarbon mildew alkenes was found.; Acinetobacter baumannii, except for 35.43% of resistance to amikacin exhibited a high antibacterial drug resistance (over 70%). Stenortrophomonas maltophilia presented a sensitive response to all of the antibiotics tested. ConclusionThe mechanism of drug resistance of non-fermentative bacteria seems to be complex, and the bacteria have a high resistance to most of clinically used antibiotics, attention should be paid to drug sensitivity tests and rational use of antimicrobial agents.

Key words: Non-fermentative, bacteria, Drug, sensitive, test, Antibiotic, resistance