Abstract: Objective Application of value of Clinical application of combined detection of plasma microRNA-27b-3p, PGR, CA15-3 and CEA in early screening and evaluation of gastric cancer. Methods One hundred patients with gastric cancer who underwent surgery in our hospital from February 2012 to February 2013 were selected as the study subjects. Another 92 patients with normal physical examination were selected as the control group. The tumor stage, tumor location, volume, differentiation degree, metastasis, infiltration, pathological type and survival of patients with TNM were analyzed. RNA-27b-3p, PGR, CA15-3 and CEA combined detection of early screening for gastric cancer and malignancy assessment value were statistically analysed. Results The levels of RNA-27b-3p, CA15-3 and CEA in the study group were significantly higher than those in the control group, while PGR was significantly lower than that in the control group. There was no significant difference in serum RNA-27b-3p, PGR, CA15-3 and CEA levels among patients with different sex, age, tumor location, size, infiltration depth, TNM stage and pathological type (P>0.05). The serum levels of RNA-27b-3p, CA15-3 and CEA in patients with lymph node metastasis exceeding 12, tumor recurrence and 5-year follow-up death were significantly increased, while PGR levels were significantly decreased. The higher the serum levels of RNA-27b-3p, CA15-3 and CEA, the lower the PGR, the higher the lymph node metastasis, tumor recurrence and follow-up death. Clearly, RNA-27b-3p, PGR, CA15-3 and CEA were independent risk factors for five year survival of gastric cancer patients. Conclusion RNA-27b-3p, CA15-3 and CEA were positively correlated with the progression of gastric cancer. PGR level was negatively correlated with the progression of gastric cancer. RNA-27b-3p, PGR, CA15-3 and CEA had positive significance in the screening and progression of gastric cancer.

Key words: MicroRNA-27b-3p, PGR, CA15-3, CEA, Gastric cancer