Abstract: Objective To analyze the sensitivity of carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii to tigecycline so as to provide an evidence for control of carbapenem-resistant bacteria neumonia. Methods One hundred and twelve specimens of carbapenem-resistant K.pneumoniae and 98 specimens of A.baumannii were collected in the hospital from 2016 to 2017. All of the isolates exhibited a broad spectrum antibiotic resistance. Results Ninety of 112 isolates (86.61%) of K.pneumoniae showed their sensitivity to tigecycline whereas 68 of 98 (69.39%) isolates of A.baumannii showed the sensitivity to tigecycline, demonstrating a higher sensitivity of K.pneumoniae to tigecycline than that of A.baumannii (P=0.001). All strains of carbapenem-resistant K.pneumoniae were found to be sensitive to tigecycline at MIC 4 mg/L when compared with A.baumannii that showed 71.21 percent of sensitivity (χ2=18.488, P=0.002). Conclusion Carbapenem-resistant K.pneumoniae has a higher antibiotic sensitivity to tigecycline than A.baumannii, suggesting a choice of use of tigecycline in control of pneumonia.

Key words: Carbapenem-resistance, Klebsiella pneumoniae, Acinetobacter baumannii, Tigecycline