Abstract: Objective To investigate the current epidemic situation of hospital infection of Acinetobacter baumannii and its resistance to antibiotics in order to provide reference for clinical treatments．Methods The retrospective analyses were performed based on the sample isolations and bacterial cultures from inpatients in the hospital from 2012 to 2016．Results A total of 2168 bacterial strains were collected. The positive rate was found to annually increase from 2012 to 2014 but it showed a gradual decrease from 2014 to 2016. Clinical isolates of A. baumannii were mainly from sputum samples. The majority of isolates came from the critical care medicine,neurosurgery,pulmonary infections,orthopedics,and geriatrics. The resistance rate of A. baumannii to antibiotics that are currently used was as high as 70 percent. The bacterial resistance to Cefoperazone was the lowest of all isolates. Conclusion The frequency of multiple drug resistance seems to be rising in spite of the decreased A.baumannii isolation in the hospital surveyed,indicating an urgent need of clinician use of antibiotics based on sensitivity test.

Key words: Acinetobacter baumannii, Drug resistance, Trend