人工肝支持系统对肝衰竭患者免疫调节作用的研究进展

doi:10.3969/j.issn.1671-2587.2025.04.021

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (4): 571-576.DOI: 10.3969/j.issn.1671-2587.2025.04.021

• 综述 • 上一篇

人工肝支持系统对肝衰竭患者免疫调节作用的研究进展

朱鑫方, 孙菲, 钟瑶, 夏荣

复旦大学附属华山医院输血科,上海 200040

收稿日期:2024-11-29 发布日期:2025-08-22
通讯作者: 夏荣,主要从事输血相关免疫研究,（E-mail）xiarongcn@126.com。
作者简介:朱鑫方,主要从事血液单采治疗及相关研究,（E-mail）279676540@qq.com。

Advances in Immunoregulation of Artificial Liver Support System for Patients with Liver Failure

ZHU Xinfang, SUN Fei, ZHONG Yao, XIA Rong

Department of Transfusion, Huashan Hospital, Fudan University, Shanghai 200040

Received:2024-11-29 Published:2025-08-22

摘要/Abstract

摘要： 人工肝支持系统是肝衰竭患者治疗过程中重要的方法,可用于肝衰竭疾病进程的任何阶段。由于肝衰竭患者病程进展时常伴随严重的免疫功能紊乱,人工肝支持系统在进行改善功能、纠正凝血功能的同时,可能同时对患者的免疫功能进行调节,如淋巴细胞和单核巨噬细胞的调节等。本文从肝衰竭患者的免疫功能变化、人工肝支持系统的工作原理以及对免疫系统的调节等方面进行了回顾性分析,为将来人工肝支持系统的发展提供研究方向。

关键词: 人工肝支持系统, 肝衰竭, 免疫调节

Abstract: The artificial liver support system constitutes a critical intervention in the therapeutic management of patients experiencing liver failure and is applicable at any stage of the disease progression. Given that the trajectory of liver failure is frequently associated with significant immune dysfunction, the artificial support system not only enhances hepatic function and improves coagulation disorders but may also concurrently modulate the patient's immune response. This modulation includes the regulation of lymphocytes and mononuclear macrophages. We conducted a retrospective analysis of various aspects, including alterations in immune function among patients with liver failure, the operational mechanisms of the artificial liver support system, and the modulation of the immune system. The findings offer a prospective research trajectory for the advancement of artificial liver support systems.

Key words: Artificial liver support system, Liver failure, Immunoregulation

中图分类号:

R575.3

朱鑫方, 孙菲, 钟瑶, 夏荣. 人工肝支持系统对肝衰竭患者免疫调节作用的研究进展[J]. 临床输血与检验, 2025, 27(4): 571-576.

ZHU Xinfang, SUN Fei, ZHONG Yao, XIA Rong. Advances in Immunoregulation of Artificial Liver Support System for Patients with Liver Failure[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(4): 571-576.

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人工肝支持系统对肝衰竭患者免疫调节作用的研究进展

Advances in Immunoregulation of Artificial Liver Support System for Patients with Liver Failure

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