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临床输血与检验

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (5): 481-483.DOI: 10.3969/j.issn.1671-2587.2016.05.026

• 临床检验研究 • 上一篇    下一篇

宝鸡市陈仓区2007~2014年新生儿TSH、Phe筛查结果分析

杜小云, 李琴, 唐凯, 梁会娟, 成艳, 张娟玲, 王文娟, 刘郁明   

  1. 721099 陕西省宝鸡市妇幼保健院
  • 收稿日期:2016-03-26 出版日期:2016-10-20 发布日期:2017-05-19
  • 通讯作者: 刘郁明,男,副主任技师,（E-mail）bjscqsczx@126.com。
  • 作者简介:杜小云（1987-）,女,陕西西安人,检验师,硕士,主要从事遗传学研究,（E-mail）yichuanshi@126.com。

Analysis of Screening Results of TSH and Phe in the Neonates of Baoji City from 2007 to 2014

DU Xiao-yun, LI Qin, TANG Kai, et al   

  1. Genetic Eugenics Laboratory of Baoji Maternal and Child Health Hospital,Shanxi,721009
  • Received:2016-03-26 Online:2016-10-20 Published:2017-05-19

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摘要： 目的 通过分析本区2007~2014年新生儿TSH、Phe的筛查结果,了解CH和PKU的发病情况,为新生儿疾病筛查制定完善有效的干预措施提供依据。方法 采集出生72 h后、正常哺乳的新生儿足跟血于特定滤纸上,应用时间分辨免疫荧光分析法检测Phe和TSH。结果 2007年7月~2014年12月,筛查新生儿25 831例,筛查率从3.02％（2007年）上升为95.52％（2014年）。CH发病率为1∶1 567（2014年）,高于全国的1∶2 099。高苯丙氨酸血症（HPA）发病率为1∶1 176（2014年）,高于全国的1∶11 376。结论 新生儿疾病筛查是减少出生缺陷、提高出生人口素质的有效手段,而本区的CH发病率和PKU发病率均高于全国平均水平,应引起当地政府及妇幼保健机构的重视。

关键词: 新生儿疾病筛查, 先天性甲状腺功能减低症, 苯丙酮尿症, 时间分辨免疫荧光法

Abstract: Objective To analyze the screening results of TSH and Phe in the neonates so as to reveal the incidence of CH and PKU in Chencang district,Baoji City, and to provide the basis for neonatal screening for the effective intervention. Methods Blood samples were taken from the heels of the 3-day old neonates,to detect Phe and TSH by using time-resolved fluoroimmunoassay. Results From July 2007 to December2014, 25831 neonates were screened. The screening rate was increased from 3. 02%（in 2007） to 95. 52%（in 2014）. The incidence of CH was 1∶1 567（in 2014）,which was higher than the national rate（1∶2 099）. Hyperphenylalaninemia（HPA） incidence was 1∶1 176（2014）,which was higher than the national rate（1∶11 376）. Conclusion Neonatal screening is an efficient measure to reduce birth defects and improve the newborn population quality. The incidence of CH and PKU was higher than the national average,suggesting that attention should be paid to this situation by the government and maternal and child health care institutions.

Key words: Neonatal screening, Congenital hypothyroidism, Phenylketonuria, Time-resolved fluor-escence immunoassay

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