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临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (3): 257-260.DOI: 10.3969/j.issn.1671-2587.2017.03.014

• 临床检验 • 上一篇    下一篇

2型糖尿病患者血清25羟维生素D3变化的相关因素分析

王萍, 李萍, 余明杰, 潘军峰   

  1. 236800 安徽省亳州市人民医院检验科（王萍,李萍,潘军峰）;
    核医学科（余明杰）
  • 收稿日期:2016-12-20 出版日期:2017-06-20 发布日期:2017-06-23
  • 作者简介:王萍（1976-）,女,安徽界首人,副主任技师,学士,主要从事生化检验工作,（E-mail）15856727887@163.com。

Analysis of the Related Factors for the Changes of Serum 25 Hydroxy Vitamin D3 in Patients with Type 2 Diabetes Mellitus

WANG ping, YU Ming jie, ZHANG Jing, et al   

  1. Department of Laboratory,People's Hospital of Bozhou,Anhui Bozhou236800
  • Received:2016-12-20 Online:2017-06-20 Published:2017-06-23

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摘要： 目的 探讨2型糖尿病患者血清25羟维生素D3与胆固醇（CHOL）、甘油三脂（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、尿白蛋白肌肝比值（UACR）、C肽（C-P）和糖化血红蛋白（HbA1c）等指标的相关性。方法 检测83例临床确诊的2型糖尿病患者血清25羟维生素D3（VitD3）、 CHOL、TG、HDL、LDL、UACR、C-P和HbA1c等指标;并根据患者血清VitD3水平进行分组,VitD3 <15 ng/ml为重度缺乏组,15 ng/ml<VitD3<20 ng/ml为轻度缺乏组,VitD3>20 ng/ml为相对正常组。结果 组间比较显示血清VitD3水平与CHOL、TG、HDL、LDL的相关性无统计学意义（P>0.05）,与UACR和HbA1c呈负相关,与C肽呈正相关,有统计学意义（P<0.05）。结论 血清25羟维生素D3与C肽、糖化血红蛋白和尿白蛋白肌肝比值联合检测可以为糖尿病患者的防治提供依据,为指导糖尿病患者自我监控、评估糖尿病肾病病变程度提供重要的参考价值。

关键词: 25羟维生素D3, C肽, 糖化血红蛋白, 尿白蛋白, 肌肝比值

Abstract: Objective To investigate the correlation between 25 hydroxy vitamin D3 （VitD3） and cholesterol（CHOL）triglycerides（TG） high-density lipoprotein（HDL） low density lipoprotein（LDL） 、 Urine albumin creatinine ratio（UACR） 、C peptide（C-P）、 glycosylated hemoglobin（HbA1c） in type 2 diabetes mellitus（T2DM）patients. Methods Serum vitamin D3（VitD3） 、CHOL、TG、 、HDL、LDL、,UACR、C-P and HbA1c detection index were determined in the 83 patients with established diabetes . And according to 25 hydroxy vitamin D3 level,the all of samples were divided into three groups,the VitD3 < 15 ng/ml for severe lack of group,15 ng/ml < VitD3 < 20 ng/ml for mild lack of group,VitD3 > 20 ng/ml for relative normal group . Results The serum VitD3 and CHOL、TG、HDL、LDL have no statistics significance among the three groups（P>0.05）. But,the level of VitD3 were negatively correlated with UACR and HbA1c; and positively correlated with C peptide; They have statistics significance among the three groups（P<0.05） . Conclusion Joint detection of VitD3、C-P and HbA1c can provide the basic information for prevention and control of diabetes,and has guiding significance in diabetes self-monitoring,and can be used as an index to assess the degree of diabetic nephropathy.

Key words: 25 hydroxy vitamin D3, C peptide, Glycosylated hemoglobin, Urine albumin, Creatinine ratio

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