Abstract: Objective To investigate the diagnostic value of IL-22,IL-27,VEGF,TF and TFPI inhibitor value in the benign and malignant pleural effusions. Method Selected ninety pleural patients were subdivided into two groups according to the Results of pathology and iconography diagnosis,ie the benign pleural effusions （benign） group with 43 cases and malignant pleural effusions （malignant） group with 47 cases. To test the diagnostic ability of several indicators used alone and in combination,the concentrations of IL-22,IL-27,VEFG,TF and TFPI were determined by ELISA Method,and the concentrations of these five biomarkers in pleural effusion were compared,then receiver operating curve （ROC） analysis was performed. Results A significant difference of IL-22,IL-27,VEGF,TF and TFPI levels were observed in patients with malignant and benign pleural effusion （P<0.05）. Receiver operating curve analysis indicated that several indicators used alone showed a less potent diagnostic ability of benign and malignant pleural effusion,the area under the ROC curve of less than 0.8; while these biomarkers used in combination showed an obvious improvement in sensitivity,specificity and accuracy. Conclusion The combination of several biomarkers can provide a reference for the differential diagnosis of benign and malignant pleural effusion. Because of the high accuracy,efficiency and simplicity,this Method is worthy promotion.

Key words: IL-22, IL-27, VEGF, TF, TFPI, Serous cavity effusion, Ros curve