Abstract: Objective To explore the effect of one-stop CT on platelet aggregation in different ways of ischemic stroke. Methods Ninety six patients with acute ischemic stroke （AIS）and hyperacute ischemic stroke（HIS）were treated in the hospital from 2014 to 2016. Patients with AIS were randomly divided into groups A,B and C while those with HIS included groups D,E and F. Both groups A and D were treated with aspirin enteric-coated tablets alone at 100 mg/ day whereas groups B and E were with clopidogrel sulfate at 75 mg/day,and groups C and F were given aspirin at 100 mg/day combined with clopidogrel at 75 mg /day. The absolute value of NIHSS,mRS,and ASPECTS scores were observed pre- and post-treatments,and the absolute value of infusion imaging parameters and clinical efficacy were observed. Results The absolute value of score in groups A and B was significantly lower than that in group C,and the value of group A was significantly lower than that of group D. The absolute value of score in group B was significantly lower than that in group E（P<0.05）. The absolute value of perfusion imaging parameters in groups A and B was significantly lower than that in group C,and the value in group A was significantly lower than that in group D. The infarcted imaging parameters in group B were decreased compered with those in group D whereas the value in group C was lower than that in group F（P<0.05）. The total effective rate of 96.87% in group C was significantly higher than that in groups A （ 84.38%）and B （83.33%）. The total effective rate in group A was 84.38%,significantly smaller than that in group D （87.50%）. The effective rate in group B was 83.33%,which was much lower than that in group E （84.38%）,and the effective rate in group C was 96.87%,smaller than that in group F （100.00%）（P<0.05）. No significant difference was seen between groups A（84.38%）and B（83.33%）（P> 0.05）. Conclusion One-stop CT before and after treatment were related to the clinical efficacy. Combined treatments may obviously decrease platelet aggregation and improve neurological function. The efficacy of the three Methods treatment in patients with hyperacute stroke was better than that of acute stroke patient.

Key words: One-stop CT examination, ASPECTS score, Ischemic stroke, mRS score