Abstract: Objective To investigate the clinical efficacy of anisodamine injection combined with azithromycin sequential therapy for the treatment of Mycoplasma pneumonia and its effect on serum inflammatory and immunological markers.Methods Eighty children infected with M. pneumonia in the hospital were randomly divided into two groups from February 2015 to February 2017. The control group was only given azithromycin,the observation group was given anisodamine injection combined with azithromycin sequential therapy. The effective rate of clinical treatment,serum cytokines and immunological indexes,the disappearance of clinical symptoms and signs,and the duration of hospitalization were compared and analyzed. Results The total effective rate of the observation group was higher than that of the control group （P<0.05）. The levels of IgA,IgM and IgG in the observation group were significantly higher than those in the control group （P<0.05）. MCP-4,MDC,CysLTs,sICAM-1,and IL-17A were found to be decreased significantly in the observation group than those in the control group （P<0.05）. The time of cough appearance in the observation group was earlier than that in the control group. The duration of fever,wheezing,lung rales and the hospitalization was shorter than that of the control group （P<0.05）. Conclusion The anisodamine injection combined with azithromycin sequential therapy in the treatment of Mycoplasma pneumonia infection may improve the clinical curative effect ,decrease the serum inflammatory cytokines and increase immunological markers,resulting in a prompt reduction of the clinical manifestations.

Key words: Anisodamine injection, Azithromycin, Mycoplasma pneumonia, Therapeutic efficacy