1 Wyres K L,Holt K E. Klebsiella pneumoniae Population Genomics and Antimicrobial-Resistant Clones[J].Trends Microbiol,2016,24(12):944-956. 2 Ramos P I,Pic?o R C,Almeida L G,et al. Comparative analysis of the complete genome of KPC-2 producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms[J].BMC Genomics,2014,15(1):54. 3 Chung P Y.The emerging problems of Klebsiella pneumoniae infections:carbapenem resistance and biofilm formation[J].FEMS Microbiology Lett,2016,363(20). 4 Campos A C,Albiero J,Ecker A B,et al.Outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae:A systematic review[J].Am J Infect Control,2016,44(11):1374-1380. 5 Wyres K L,Gorrie C,Edwards D J,et al.Extensive Capsule Locus Variation and Large-Scale Genomic Recombination within the Klebsiella pneumoniae Clonal Group 258[J].Genome Biol Evol,2015,7(5):1267-1279. 6 Shu H Y,Fung C P,Liu Y M,et al.Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates[J].Microbiology,2009,155(12):4170-4183. 7 Domenico.P,Salo.R,Cross.S,et al.Polysaccharide capsule-mediated resistance to opsonophagocytosis in Klebsiella pneumoniae[J]. Infect Immun,1994,62(10):4495-4499. 8 Campos M A,Vargas M A,Regueiro V,et al.Capsule Polysaccharide Mediates Bacterial Resistance to Antimicrobial Peptides[J].Infect Immun,2004,72(12):7107-7114. 9 Chen L,Chavda K D,Findlay J,et al.Multiplex PCR for identification of two capsular types in epidemic KPC-producing Klebsiella pneumoniae sequence type 258 strains[J].Antimicrob Agents Chemother,2014,58(7):4196-4199. 10 Cerqueira G C,Earl A M,Ernst C M,et al.Multiinstitute analysis of carbapenem resistance reveals remarkable diversity,unexplained mechanisms,and limited clonal outbreaks[J].Proc Natl Acad Sci USA,2017,114(5):1135-1140. 11 Held T K,Adamczi k C,Trautmann M,et al.Effects of MICs and subMICs of antibiotics on production of capsular polysaccharide of Klebsiella pneumoniae[J]. Antimicrob Agents Chemother,1995,39(5):1093-1096. 12 Huang T W,Lam I,Chang H Y,et al.Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578[J].BMC Research Notes,2014,7(1):13. 13 Wang H,Wilksch J J,Strugnell R A,et al.Role of Capsular Polysaccharides in Biofilm Formation:An AFM Nanomechanics Study[J].ACS Appl Mater Interfaces,2015,7(23):13007-13013. 14 Clegg S,Murphy C N.Epidemiology and Virulence of Klebsiella pneumoniae[J].Microbiol Spectr,2016,4(1). 15 Wu M C,Lin T L,Hsieh P F,et al.Isolation of genes involved in biofilm formation of a Klebsiella pneumoniae strain causing pyogenic liver abscess[J].PLoS One,2011,6(8):e23500. 16 Goncalves Mdos S,Delattre C,Balestrino D,et al.Anti-biofilm activity:a function of Klebsiella pneumoniae capsular polysaccharide[J].PLoS One,2014,9(6):e99995. 17 Lin C L,Chen F H,Huang L Y,et al.Effect in virulence of switching conserved homologous capsular polysaccharide genes from Klebsiella pneumoniae serotype K1 into K20[J].Virulence,2017,8(5):487-493. 18 Chen Y J,Chen S Y,Wang J T,et al.Mycotic aneurysm caused by gas-forming serotype K5 Klebsiella pneumoniae[J].Int J Infect Dis,2009,13(2):e47-e48. 19 Fang C T,Lai S Y,Yi W C,et al. Klebsiella pneumoniae genotype K1:an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess[J]. Clin Infect Dis,2007,45(3):284-293. 20 Liao C H,Huang Y T,Lai C C,et al.Klebsiella pneumoniae bacteremia and capsular serotypes,Taiwan[J].Emerg Infect Dis,2011,17(6):1113-1115. 21 March C,Cano V,Moranta D,et al.Role of bacterial surface structures on the interaction of Klebsiella pneumoniae with phagocytes[J].PLoS One,2013,8(2):e56847. 22 Moranta D,Regueiro V,March C,et al.Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells[J]. Infect Immun,2010,78(3):1135-1146. 23 Bj?rkman J,Andersson D I.The cost of antibiotic resistance from a bacterial perspective[J].Drug Resistance Updates,2000,3(4):237-245. 24 Kn?ppel A,Lind P A,Lustig U,et al.Minor fitness costs in an experimental model of horizontal gene transfer in bacteria[J]. Mol Biol Evol,2014,31(5):1220-1227. 25 Choi M J,Ko K S.Loss of hypermucoviscosity and increased fitness cost in colistin resistant Klebsiella pneumoniae sequencetype 23 strains[J].Antimicrob Agents Chemother,2015,59(11):6763-6773. 26 Bachman M A,Breen P,Deornellas V,et al.Genome-Wide Identification of Klebsiella pneumoniae Fitness Genes during Lung Infection[J]. MBio,2015,6(3):e00775-15. 27 Zhou K,Lokate M,Deurenberg R H,et al. Characterization of a CTX-M-15 Producing Klebsiella Pneumoniae Outbreak Strain Assigned to a Novel Sequence Type (1427)[J].Front Microbiol,2015,6:1250. 28 Wright M S,Perez F,Brinkac L,et al.Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals[J].Antimicrob Agents Chemother,2014,58(8):4961-4965. |