Abstract: Objective To investigate the expression,clinical value and significance of ER beta 2 and ER alpha 46 in papillary thyroid carcinoma （PTC）. Methods The 40 cases of papillary thyroid carcinoma,40 normal thyroid tissues and 40 nodular goiter,were selected. Immunohistochemical technique （Immunohistochemistry,IHC） was used to detect the expression of ER beta 2 and ER alpha 46 in tissue,and the preoperative lymph node metastasis,clinical stage and 5 year survival rate of PTC patients were collected. Results The positive expression rates of ER beta 2 and ER 46 in papillary thyroid carcinoma were 92.5% and 70% respectively,and the positive expression of 2 kinds of receptors in papillary thyroid carcinoma and benign lesion were statistically significant（P<0.05）.The sensitivity of ER beta 2 ER alpha 46,the diagnosis of papillary carcinoma were 92.5% and 70.0% respectively,the specificity was 72.5% and 78.8%; ER beta 2,ER alpha 46 expression with papillary thyroid carcinoma clinical stage and lymph node metastasis,the differences were statistically significant（P<0.05）,and the 5 year survival and death patients that ER beta 2 and ER alpha 46 positive cell rate difference were no statistical significance（P>0.05）. Conclusion The expression of ER beta 2 and ER alpha 46 is increased in papillary thyroid carcinoma,and has some value in pathological diagnosis,but it is not obvious for judging the long-term prognosis.

Key words: Estrogen receptor, Papillary thyroid carcinoma, Clinicopathological features, Er beta 2, ER alpha 46