Abstract: Objective To obtain genetic parameters of X-STR loci,we analysed and compared the distribution frequency in Han population and Zhuang population in Guangxi province. Methods 1 267 healthy adults in Guangxi were detected with twelve X-STR's subtypes such as DXS8378 by Investigator Argus X-12 KIT. 612 cases Han population were regarded as the control group and 655 cases Zhuang population as the study group. Genotype distribution frequency and genetic parameters of the two groups were compared. Results （1）Genotype distribution frequency of two groups were all consistent with Hardy-Weinberg equilibrium. 128 genotypes were detected in Han population and genotype distribution frequency was 0.002 9~0.787 2. 145 genotypes was detected in Zhuang population and genotype distribution frequency were 0.003 5~0.658 1.（2）The PIC of Han population was 0.388 6~0.896 6 and the PIC of Zhuang population was 0.405 9~0.889 3.The Heterozygosity of Han population was 0.379 6~0.809 1 and the Heterozygosity of Zhuang population was 0.501 8~0.825 5. The MECduo and MECtrio of Han population was 0.367 7~0.685 0 and 0.4357~0.8421,and the MECduo and MECtrio of Zhuang population was 0.423 3~0.821 7 and 0.475 5~0.912 8. The DP and EP of Han population was 0.555 8~0.872 2 and 0.471 1~0.822 7,and the DP and EP of Zhuang population was 0.787 4~0.978 1 and 0.520 1~0.864 7. Conclusions Genotype distribution frequency of two groups are all consistent with Hardy-Weinberg equilibrium. But the X-STR loci in Zhuang population are highly polymorphic,which is different from that of Han population. It has certain guiding significance for paternity identification in forensic medicine in this region.

Key words: Guangxi, Zhuang population, X-STR, Genetics