Abstract: Objective To observe the clinical effect of closed negative pressure drainage （VSD） combined with silver ion irrigation in the treatment of infection wounds in Department of orthopedics. Method s106 cases of wound infection in Department of orthopedics in our hospital from September 2015 to March 2017 were randomLy divided into observation group and control group,53 cases in each group,the observation group was given VSD combined with silver ion washing treatment,the control group only received routine VSD treatment,observe the therapeutic effect and complications,record control time and hospitalization time two the frequency of dressing,infection,respectively before treatment,after 3 weeks of treatment in two groups were detected with white blood cell count,erythrocyte sedimentation rate and C-reactive protein C. Results The treatment effect of observation group was higher than the control group,the number of dressing changes,infection control time,hospitalization time,complication rate,leukocyte count,erythrocyte sedimentation rate and C-reactive protein C were lower than the control group,the difference was statistically significant （P<0.05）. Conclusion The application of VSD combined with silver ion irrigation in the treatment of wound infection in Department of orthopedics can improve the treatment effect,shorten the cure time of patients,and promote the patients to leave hospital as soon as possible.

Key words: Closed negative pressure drainage, Silver ion irrigation, Wound infection in Department of Orthopedics, Clinical effect, Laboratory index