Abstract: Objective To investigate the concentrations of serum adiponectin （APN）,cystatin C （CysC）,osteopontin （OPN） and immunoglobulin A1 （IgA1） in children with purpura nephritis and explore their significance in the diagnosis of the disease. Methods Thirty-nine children who received treatments in the hospital during the past two years were selected as HSPN group and 50 healthy subjects were enrolled in parallel. Enzyme-linked immunosorbent assay was used to detect the levels of APN,CysC,OPN and IgA1 in the two groups. The incidence of HSPN and the concentrations of APN,CysC,OPN and IgA1 were analyzed by SPSS Pearson correlation analysis software. Results Serum adiponectin in HSPN group was lower than that in control group （P<0.05）. The levels of cystatin C,osteopontin and immunoglobulin A1 in HSPN group significantly increased （P<0.05）. The incidence of HSPN was negatively correlated with the serum APN （P<0.05）,but positively correlated with the concentrations of CysC,OPN,and IgA1 （P<0.05）. Conclusion Detection of serum APN,CysC,OPN and IgA1 is useful in assessment of occurrence,progress and severity of the disease.

Key words: Henoch-Schonlein, Purpura nephritis, Adiponectin, Cystatin C, Osteopontin, Immunoglobulin A1