Abstract: Objective to analyze the effect of Nintedanib on endothelin-1 and angiotensin in patients with pulmonary fibrosis. Methods Eighty patients with pulmonary fibrosis were followed up from 2016 to 2018. The patients were randomly divided into the control group (n=40) and observation group (n=40) and treated with routine therapy combined with Nintedanib for 4 weeks. The efficacy and adverse reactions were monitored in hospital. Results The curative effect in the observation group was significantly increased compared to that in the control (P<0.05). The serum levels of endothelin-1 and angiotensin and scoring of chest radiographs, in the patients of both groups were decreased following treatments (P<0.05) but more remarkably in the observation group than the control group (P<0.05). Conclusion Nintedanib adjuvant treatment for pulmonary fibrosis may improve the curative effect and inhibit lung fibrosis, showing down-regulation of endothelin -1 and angiotensin production.

Key words: Pulmonary fibrosis, Endothelin-1, Angiotensin, Nintedanib