Abstract: Objective To investigate the prevalence of Hyperuricemia （HUA） in coastal areas of shenzhen, and to explore the correlation between HUA and SLC2A9 gene rs2241480 site polymorphisms, providing scientific basis for HUA diagnosis and treatment. Methods 2 753 people living in coastal areas from march to July 2018 were randomly selected, serum uric acid （UA） level was detected by AU5800 automatic biochemical analyzer, and SLC2A9 gene rs2241480 polymorphisms of HUA patients and 120 non-HUA people were detected by Sequenom Mass Array iPlex Gold technology, and the test results were statistically analyzed. Results among 2 753 people, 425 cases of HUA were detected, the prevalence rate was 15.44%, among which 18.27% is in male and 11.55% was in female, and the difference was statistically significant （χ²=3.782 1, P<0.05）. > 60 years old group is the highest incidence of HUA, at 30.67%, followed by 51 to 60 years old group, then 41 to 50 years old, 21.18% and 15.09%, respectively, between each age group are statistically significant differences （χ²=2.168 3 ~3.418 6, P<0.05）, and HUA prevalence rates were higher in men than in female at below 60 years old groups , difference was statistically significant （χ²=2.761 5~3.905 2, P<0.05）, but > 60 years old group HUA prevalence of women more than men,difference was statistically significant （χ²=2.036 5, P<0.05）. The detection rates of CC, CT and TT genotypes at the rs2241480 loci of SLC2A9 in the HUA group were 44.71%, 30.82% and 24.47%, respectively. The detection rates of CC genotypes were 18.33%, 37.50%and 44.17% in the non-HUA group, respectively. The detection rates of CC genotypes in the HUA group were higher than those in the non-HUA group, with statistically significant differences （χ²=5.162 5, P<0.05）. The C allele frequency in the HUA group was 60.12%, significantly higher than it is 37.08% in the non-HUA group, and the difference was statistically significant（χ²=3.602 4, P<0.05）. Conclusion the prevalence rate of HUA in coastal areas of shenzhen is above the average level in China, and it is younger. SLC2A9 gene rs2241480 locus polymorphism has some correlation with HUA, and CC genotype and C allele might be pathogenic genes of HUA in this region.

Key words: Coastal areas, Hyperuricemia, SLC2A9 gene, Mononucleotide polymorphisms