Abstract: Objective By investigating the clinical use of blood for single disease, statistics and analysis of blood usage of neonates with hyperbilirubinemia receiving exchange transfusion therapy in our hospital were conducted to provide valuable evidence for rational blood storage in blood transfusion department, planned blood supply at blood station and rational clinical use of blood in clinic. Methods The clinical data of 389 neonates with hyperbilirubinemia receiving exchange transfusion therapy in our hospital between January 2016 and December 2019 were retrospectively analyzed. Data of patient's general condition were provided and the volumes of blood used for the exchange transfusion therapy were analyzed. Results Among the 389 cases of exchange transfusion, 212 cases were males, 177 cases were females. There was no statistically significant gender difference (P>0.05). One hundred and fifty five cases were blood type A, 128 cases were blood type B, 80 cases were blood type O, and 26 cases were blood type AB. There was significant difference between blood types (P<0.001). Among patients with hyperbilirubinemia, blood type O had the least volumes of blood for exchange, and there was no significant difference between blood type A and blood type B (P>0.05). Type O packed red blood cells and type AB fresh plasma were the most choice for exchange transfusion therapy. The amount of blood type O packed red blood cells was 1 060U, accounting for 86.14%. The amount of blood type AB plasma was 49 050 mL, accounting for 75.81%. The average transfusion used in each case was 3.13 units of packed red blood cells and 165 mL of fresh frozen plasma. Conclusion Through the analysis of exchange transfusion in severe neonatal hyperbilirubinemia, we summarized the experience of blood use for exchange transfusion, which will help blood transfusion department to develop a blood storage plan, provide evidence for optimizing transfusion practice. While effective treatment, Rational use of blood and saving blood have been emphasized.

Key words: Neonatal hyperbilirubinemia, Exchange transfusion, Reasonable use